2006年全国自身抗体检测质量控制总结  

Summary of the nation-wide autoantibodies test quality survey in 2006

作　　者：黄烽[1] 丛贤滋[1] 李小峰[1] 张江林[1] 丁玉珍[1] 

机构地区：[1]解放军总医院风湿科,北京100853

出　　处：《中华风湿病学杂志》2008年第6期382-385,共4页Chinese Journal of Rheumatology

摘　　要：目的 了解我国自身抗体检测的现状，促进自身抗体检测水平的提高。方法 以自愿报名的方法确定参与单位。质量控制项目包括抗核抗体（ANA）、抗双链DNA（dsDNA）抗体）、抗可提取核抗原（ENA）抗体、抗线粒体抗体（AMA），抗平滑肌抗体（ASMA）、抗环瓜氨酸肽抗体（抗CCP）5项，共15份标本。标本发放及结果分析采用双盲操作。结果 共55家医院，科室参加质量控制活动。本次ANA、抗dsDNA抗体、AMA／ASMA和CCP的正确率分别为92％、89％、96％、72％，抗ENA按抗RNP、Sm、SSA、SSB和Scl-70分别分析，正确率分别为98％、89％、92％、75％、77％。结论 我国自身抗体检测情况与前3次质控相比，检测的项目逐年增多，检测水平逐步提高。Objective To consecutively understand the current national clinical testing quality and enforce quality-control of auto-antibody detection. Methods Hospitals or departments were recruited by letters or telephone communications. The autoantibodies examined for quality control survey included antinuclear antibodies （ANA）, anti-double-stranded DNA （A-dsDNA） antibody, anti-extractable nuclear antigens （A-ENA） antobodies, anti-mitochondria antibody （AMA）/anti-smooth muscle antibody （ASMA）, and anti-CCP antibody. Each autoantibody was tested in 3 samples, and altogether 15 samples in total for testing. Sample designation and testing results data analysis were double-blinded. Results Fifty-five hospitals/departments participated in this survey. The accuracy rates for this survey were 92%, 89%, 96%, 72% respectively for ANA, A-dsDNA, AMA/ASMA, and anti-CCP. Anti-ENAs were further divided into anti- . RNP, Sm, SSA, SSB and Scl-70 subgroups, and the accuracy rates were 98%, 89%, 92%, 75% and 77% respectively. Conclusion Compared to the previous 3 national surveys, accuracy rates in our country＇s autoantibody testing is increaseing steadly with more testing items included each year. This indicats that the quality of auto-antibody testing is improving across the country.

关 键 词：自身抗体 免疫学试验 质量控制 

分 类 号：R446.6[医药卫生—诊断学]