重庆地区无偿献血者丙肝病毒感染及对献血者招募的影响(英文)  

HCV Infection in Voluntary Donors and Its Influence on Recruitment of Donors in Chongqing Area

作　　者：赵树铭[1,2] 蒋天伦[1] 黎儒青[1] GAO Feng-Xiang LU Ling ZHENG Hao-Qiang 胡建[1] 范娅涵[1] 李兵[1] 肖瑞卿[1] Yury Khudoyakov 

机构地区：[1]第三军医大学西南医院输血科,重庆400038 [2]Division of Hepatitis Virus, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA [3]Division of Gastroenterology/Hepatology, Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66045, USA

出　　处：《中国实验血液学杂志》2008年第3期676-680,共5页Journal of Experimental Hematology

基　　金：美国公共卫生实验室协会(APHL)资助~~

摘　　要：近年来,中国的献血者招募模式正在从有偿献血到单位组织献血,进而到完全无偿献血的模式转变。有关真正的无偿献血者中丙型肝炎感染的资料还较少报道。本研究对重庆地区2003年的首次献血者进行丙型肝炎感染及病毒分型的调查,共有13620份血清标本进行ELISA丙型肝炎抗体检测,其中抗体阳性标本再经RT-PCR扩增HCVRNA的核心区/E2区片段进行基因分型。结果发现,HCV抗体阳性率为0.49%(67/13620),其中在40-49岁年龄段的阳性率(0.86%)最高;高学历人群和大城市生活人群的阳性率相对为高。丙肝病毒的基因分型结果显示,在22份基因分型阳性标本中有基因型1b,2a,3a和3b等四种,分别占4(18%)、5(23%)、9(41)和4(18%),以基因型3(包括3a和3b)为流行。结论:重庆地区无偿献血人群中丙型肝炎抗体阳性率较低;由于本地及周边地区静注毒品人群中丙型肝炎感染以基因型3为主,提示可能在献血人群中有静注吸毒者的存在。因此,随着献血模式的转变,在献血者的招募中应注意排除吸毒者这一高危人群。Blood donor recruitment models have changed from paid donors to employer-organized donors and to voluntary donors in China. Reports on the hepatitis C virus （HCV） infection among voluntary blood donors in China have been rarely found at present. The prevalence of anti-HCV and genotypes among the first-time voluntary blood donors was investigated in Chongqing area of China. A total of 13620 serum samples were collected from the first-time voluntary blood donors in Chongqing, China. Anti-HCV antibody was tested by ELISA. The Core/E2 region of HCV RNA from HCV seropositive samples was amplified by RT-PCR for genotyping. The results indicated that the prevalence of anti-HCV averaged 0. 49% （67/ 13620）, and the highest rate （0.86%） was obtained in the group aged 40 to 49. A higher prevalence was observed among the more educatied donors, and metropolitan donors. The ratios of following genotypes lb, 2a, 3a and 3b were 4 （ 18% ）, 5 （23%）, 9（41% ） and 4（18% ） in all the 22 samples respectively. Genotype 3 （3a and 3b） was the predominant genotype. In conclusion, the prevalence of anti-HCV was low among the population of voluntary blood donors in Chonqing area. The genotyping results showed the possibility of presence of druggies among the voluntary blood donors. Therefore, more attention should be paid to exclude those high-risk persons from the volunteers.

关 键 词：丙型肝炎病毒 丙型肝炎病毒感染 基因型 无偿献血者 

分 类 号：R457.1[医药卫生—治疗学] R512.63[医药卫生—临床医学]