硅橡胶中纳米二氧化钛对白色念珠菌生长影响的初探  

Effect of Candida albicans growth on silicone elastomer containing nano-TiO2

作　　者：李蓓[1] 赵铱民[1] 杨聚才[2] 韩颖[1] 董智伟[1] 

机构地区：[1]第四军医大学口腔医学院修复科,西安710032 [2]第四军医大学口腔医学院检验科,西安710032

出　　处：《中华口腔医学杂志》2008年第6期367-369,共3页Chinese Journal of Stomatology

基　　金：国家自然科学基金（30471908）

摘　　要：目的通过研究纳米二氧化钛对硅橡胶体外抗白色念珠菌性能的影响，探讨用纳米二氧化钛改善硅橡胶抗白色念珠菌性能的可靠性。方法硅橡胶中加入质量分数分别为0．5％、1．0％、1．5％、2．0％的纳米二氧化钛抗菌剂，分别记为A、B、C、D组，对照组硅橡胶不加纳米二氧化钛，采用薄膜密着法在光照和无光照条件下测定各组硅橡胶对白色念珠菌的抗菌作用。结果光照条件下，A、B、C、D组菌落数[分别为（439．0±21．9）CFU、（289．3±7．8）CFU、（173．0±7．6）CFU、（86．7±3．9）CFU]与对照组[（597．3±5．5）CFU]的差异均有统计学意义（P〈0．05）；非光照条件下，A、B、C、D组菌落数[分别为（543．7±22．8）CFU、（478．0±17．0）CFU、（422．7±21．8）CFU、（283．0±12．1）CFU]与对照组[（611．3±10．0）CFU]的差异均有统计学意义（P〈0．05）。D组抗菌性能最好，无光照条件下，抑菌率为53．7％；光照条件下，抑菌率可达85．9％。结论添加了纳米二氧化钛抗菌剂的硅橡胶在光照和无光照条件下均能抑制白色念珠菌生长，随着纳米二氧化钛质量分数的增加，硅橡胶抑菌效果增强。纳米二氧化钛质量分数相同时，光照下硅橡胶的抑菌性比无光照强。Objective To study the antibacterial effect against Candida alb/cans of the A-2186 silicone elastomer containing nano-TiO2 in vitro. Methods Antibacterial agent of nano-TiO2 was added into A-2186 silicone elastomer with incorporating percentages of 0. 5%, 1.0%, 1.5%, and 2. 0% （W/W）. There was no nano-TiO2 in the control group. The antibacterial effect of the A-2186 silicone elastomer was determined using the film contact method with lighting and without lighting. Results Either with lighting or without lighting, there were signiilcances between the experiment groups and the control group （P 〈 0. 05 ）. When the incorporating percent was 2. 0%, the inhibitory effect was the best among the experiment groups. Without lighting, the inhibitory rate was 53.7% and with lighting, the inhibitory rate was 85.9%. Conclusions The A-2186 silicone elastomer containing usno-TiO2 has antibacterial properties against Cand/da a/b/cans, which enhances with increases of nano-TiO2 percent in the material With the same incorporating percentage, the antibacterial effect with lighting is better than that without lighting.

关 键 词：弹性聚硅酮类 念珠菌 白色 纳米结构 二氧化钛 

分 类 号：R686[医药卫生—骨科学]