部分换血治疗新生儿红细胞增多症的临床研究  

Clinical study in partial exchange transfusion for the treatment of neonatal plycythaemia

作　　者：龙苹 陈继昌 林墨菊 蒋健穗 廖燕玲 李翠玉 

机构地区：[1]广西柳州市妇幼保健院新生儿科,545001

出　　处：《中国妇幼保健》2008年第17期2386-2388,共3页Maternal and Child Health Care of China

基　　金：广西卫生厅自筹经费课题(NO.Z2005180)

摘　　要：目的：探讨部分换血治疗新生几红细胞增多症（NP）的疗效及血液流变学的变化。方法：96例NP患儿随机分为观察组和对照组各48例，两组患儿均给予常规对症处理及静脉点滴复方丹参，在此基础上观察组给予部分换血治疗，换血量平均为43ml。观察指标包括治疗转归、临床症状改善情况和血液流变学的变化。结果：观察组治愈率达100％（48／48），对照组治愈40例（83．3％），好转8例（16．7％）；观察组临床症状改善平均时间及平均住院时间与对照组比较差异均有统计学意义（P〈0．001）；观察组血液流变学相关指标的改善程度与对照组比较差异均有统计学意义（P〈0．05～0．001）。结论：根据NP病情的轻重，采用8～10ml／kg或11～20ml／kg换血量治疗，此疗法安全，能显著提高疗效，迅速改善临床症状，值得临床应用。Objective： To explore the effects and hemorrheology of partial exchange transfusion （PET） for the treatment of neonatal polycythaemia （NP） . Methods： 96 neonates with NP were randomly divided into the PET group （ PET with routine fluid and salvia mihiorrhiza compound injection） and the control group. Results： The cure rate in PET group was 100% （48/48） , the cure rate in control group was 83.3% （40/48） ; The mean recovery time and the mean hospitalization time in PET group were significantly less than that in control group （P 〈 0. 001 ） . The index of hemorheology in PET group was better than that in control group （all P 〈 0. 05 - 0. 001 ） . Conclusion： According to the serious degree of the disease, the dose of exchanging fluid 8 - 10 ml/kg or 11 -20 ml/kg is safe and effect. PET can improve clinical symptom swift by making low shearing total blood viscosity, high shearing total blood viscosity and erythrocyte index of rigidity fall down.

关 键 词：新生儿 红细胞增多症 部分换血 血液流变学 

分 类 号：R722[医药卫生—儿科]