磷脂酰肌醇蛋白聚糖3在人大肠癌组织中的表达  

Expression and significance of glypican-3 in colorectal cancer

作　　者：袁东红[1] 谢华红[1] 王燕[1] 孟存英[2] 杨利萍[1] 冯亦朝[2] 宋久刚[1] 邹学[1] 吴开春[1] 刘杰[1] 

机构地区：[1]第四军医大学西京医院消化病研究所国家肿瘤生物学重点实验室,西安710032 [2]延安大学医附院消化内科

出　　处：《中华医学杂志》2008年第22期1540-1542,共3页National Medical Journal of China

基　　金：国家自然科学基金资助项目（30371585、30570835）;国家高技术研究发展“863”计划基金资助项目（2006AA022468）

摘　　要：目的探讨磷脂酰肌醇蛋白聚糖3（Glypican-3）在大肠癌组织及癌旁组织中的表达、分布及意义。方法采用免疫组化方法检测Glypican-3在200例大肠癌及其癌旁组织中的表达，分析其表达的意义。结果大肠癌中Glypican-3阳性率为66．0％（132／200），明显高于癌旁组织[24．0％（48／200）]，差异有统计学意义（P=0．019）。Glypican-3的表达与大肠癌组织浆膜浸润、淋巴结转移有相关性（P=0．015）。结论Glypican-3在人大肠癌中表达增加，与大肠癌的浸润、淋巴结转移相关。Objective To investigate the expression and significance of Glypican-3 in colorectal cancer. Methods Immunohistochemistry was used to detect the expression of Glypican-3 in 200 specimens of colorectal cancer and adjacent non-cancerous tissues resected during operation. Results Glypican-3 immunoreactivity was recognized in both the cytoplasm and cellular membrane. The Glypican-3 positive expression rate in the tumor samples was 66.0% （132/200）, significantly higher than that in the adjacent nontumor tissues （24%, 48/200, P = 0.019）. The Glypican-3 expression rate was significantly correlated with the carcinoma invasion （P =0.023） and lymph node metastasis （P =0.015）, but not associated with gender, age, tumor size, and differentiation grade （ all P 〉 0. 05 ）. Conclusion Over-expression of Glypican-3 may play an important role in the genesis and development of colorectal cancer, and may be used as a new biological parameter in predicting invasion and metastasis of colorectal carcinoma.

关 键 词：肠肿瘤 免疫组织化学 磷脂酰肌醇蛋白聚糖3 

分 类 号：R686[医药卫生—骨科学]