β-TCP植入人体骨缺损后的组织学观察  

The histological study of Porous β-Tricalcium Phosphate Ceramic in the Human Bone Defect

作　　者：史定伟[1] 谢幼专[1] 朱振安[1] 张蒲[1] 唐坚[1] 孙月华[1] 汤亭亭[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院骨科,上海200011

出　　处：《生物骨科材料与临床研究》2008年第3期8-10,共3页Orthopaedic Biomechanics Materials and Clinical Study

基　　金：国际科技合作重点项目(2005DFA30120);国家自然科学基金项目(30600629);上海市科委资助项目(07pJ14068)

摘　　要：目的了解多孔β-TCP在植入人体后的的成骨变化及降解过程。方法对12例多孔β-TCP活检标本行不脱钙硬组织切片检查观察陶瓷周围和内部的新生组织、陶瓷的形态改变、降解颗粒及伴随的细胞吞噬反应。其中11例标本行组织形态计量。结果所有的β-TCP标本均可见新生骨组织,新骨与材料紧密接触;材料的结构变得稀疏,周围可见降解颗粒和吞噬细胞。新生骨组织(VPB)为21.83%,材料残余率为21.17%。结论多孔β-TCP是一种良好的骨传导材料,植入体内后能逐步降解并形成新生骨组织。陶瓷产生的降解颗粒及诱发的细胞吞噬反应应引起注意。Objective To reveal the osteogenesis and the biodegradation of the porousβ-tricalcium phosphate ceramic （β-TCP） in the human bone defect. Methods The undecalcified histological study was carried out on 12β-TCP samples. The tissue in or around the material, the change of ceramic shape; the particles and the presence of macrophages were observed. The quantitative study was performed in 11 samples. Results Newly formed bone was found in all the samples. The newly formed bone was closely integrated with the material. The normal structure ofβ-TCP disappeared. The degrad- ation particles were present both in the macrophages and around the tissue. New bone formation rate was 21.83% and the residual material rate was 21.17%. Conclusion The β-TCP is a kind of good osteoconductive material. It will degrade gradually with the new bone formation. The degradation particles and the phagocytotic activity have been noted.

关 键 词：骨缺损 Β-磷酸三钙 骨形成 生物降解 

分 类 号：R318.08[医药卫生—生物医学工程]