天鹅记忆接骨器体内生物相容性研究  

The biological compatibility of Swan-like memory connecter (SMC) after long-time internal fixation

作　　者：王仁[1] 张春才[2] 付青格[2] 禹晓东[1] 许硕贵[2] 

机构地区：[1]解放军第451医院骨科,陕西西安710054 [2]第二军医大学长海医院骨科,上海200433

出　　处：《生物骨科材料与临床研究》2008年第3期11-14,共4页Orthopaedic Biomechanics Materials and Clinical Study

摘　　要：目的探讨NiTi合金天鹅记忆接骨器(SMC)在人体长期植入后的生物相容性。方法从临床上肢长管状骨骨折病例中随机选取病例,分别采用SMC内固定和进口不锈钢板内固定。待骨折愈合后手术取出内固定的同时取少量与金属密切接触的软组织界膜进行大体、光镜及电镜观察,比较不同性质内固定材料对骨折周围软组织的影响。结果SMC组软组织均无肉眼可见的炎性反应,为规则致密的纤维结缔组织,成纤维细胞为主要细胞成分,与正常纤维组织相连续,所在局部无明显软组织异常增生及变性,组织修复过程良好,未见变色、腐蚀和明显异物反应迹象;而不锈钢组则出现了较之严重的炎性反应,组织结构紊乱、成纤维细胞形态与周围胶原纤丝紊乱。结论SMC固定骨折后其对局部损害较轻,炎症反应轻或无,生物相容性及耐腐蚀性表现优于不锈钢板,是一种理想的生物医用材料。Objective To assess the biological compatibility of Swan-like memory connecter （SMC） after long-time internal fixation. Methods SMC or stainless steel plates were randomly fixed into patients who had upper limb fractures. When internal fixators were taken out, the local soft tissues which tightly contacted metals were obtained and observed grossly, histologically and ultrastructurally. The effects of different fixators on local soft tissues were compared. Results The local soft tissues of SMC group, which were continuous with normal fibrous tissue, had regular fiber distribution and none inflammatory reaction. The main component cells were fibroblasts. No obvious hyperplasia and degeneration were observed and there was no discoloration, corrosion and foreign body reaction. Stainless steel plate group had more inflammatory reaction and disordered local soft tissues. Fibroblast was disordered with collagen fiber. Conclusion Compared with stainless steel plates, SMC made less local lesions and minor inflammation. SMC has good biological compatibility and corrosion resistance, and is an ideal biological material for medicine use.

关 键 词：NITI合金 天鹅记忆接骨器 骨折 生物相容性 内固定 

分 类 号：R318.08[医药卫生—生物医学工程]