利用脂肪酸合成酶为新靶点的筛选模型与platensimycin  

Novel-type antibiotics using Fab as target and Platensimycin

作　　者：罗威[1] 顾觉奋[1] 

机构地区：[1]中国药科大学生命科学与技术学院,南京210009

出　　处：《中国抗生素杂志》2008年第6期321-324,332,共5页Chinese Journal of Antibiotics

摘　　要：本文概述了以β-酮脂酰-ACP合成酶(Fab)为靶点的新型抗生素的开发背景、筛选模型的构建以及最新筛选成果。并对一种很有希望用于临床的Fab抑制剂platensimycin进行了详细介绍。A novel type of antibiotics with a new mechanism involving the inhibition of Fab enzyme （β-ketoacyl-[acyl carrier protein] synthases） was summarized in this article, including the background of the research and development of the screen model as well as the results of screening a promising new Fab inhibitor platensimycin, which had the potential to be introduced into clinical use in the future was described, in detail.

关 键 词：β-酮脂酰-ACP合成酶 反义RNA 双平板鉴定 耐药菌 PLATENSIMYCIN 

分 类 号：R978.1[医药卫生—药品]