过敏性紫癜发病机制的研究进展  

The progress on pathogenesis of Henoch-Schonlein purpura(Review)

作　　者：吕丹[1] 陈光仍[1] 燕华玲[1] 白琴玉[1] 

机构地区：[1]青海大学医学院,青海西宁810001

出　　处：《皮肤病与性病》2008年第2期13-15,共3页Dermatology and Venereology

摘　　要：过敏性紫癜在临床上发病率仍然很高,合并肾损害将严重影响患者的生存质量,而其发病机制目前尚未完全阐明,因此其发病机制仍然是目前研究的热点。近年众多学者对该病发病机制的研究取得较大进展,发现一部分因素。T细胞功能改变、细胞间粘附因子-1、P选择素、内皮素、一氧化氮、血管性假血友病因子、D-二聚体、基因在过敏性紫癜的发病中起着重要的作用。本文就目前过敏性紫癜发病机制的研究进展作一综述。The morbidity of Henoeh - Schonlein purpura remains high in the clinic, renal complicahon could seriously affect the quality of life of the patients, and its pathogenesis has not been well explained Its pathogenesis is now focused in the recent studies.. In recent years, many researchers study the pathogenesis of this disease which made great progress in the influence factors. The changes of T cell function, ICAM- 1 ,P- selectin ,endothetin, nitric oxide, von willebrand factor, D -dimer and gene in the Henoch -Schonlein play an important role in the incidence. The current progress in pathogenesis is reviewed in this paper.

关 键 词：紫癜过敏性 发病机制 研究 

分 类 号：R554.6[医药卫生—血液循环系统疾病]