A771726大鼠在体小肠吸收动力学  

The intestinal absorption kinetics of A771726 in rats

作　　者：朱熙[1] 李俊[1] 金涌[1] 李淑娟[1] 

机构地区：[1]安徽医科大学药学院,合肥230032

出　　处：《安徽医科大学学报》2008年第3期301-304,共4页Acta Universitatis Medicinalis Anhui

摘　　要：目的探讨A771726大鼠在体各肠段的吸收动力学特征。方法采用大鼠在体小肠回流装置,以UV法和HPLC法分别测定酚红和A771726的含量。结果大鼠十二指肠?空肠?回肠?结肠2h后对A771726的吸收百分率分别为36.0%±2.1%、27.5%±4.2%、38.1%±5.1%、22.5%±2.3%,吸收速率常数分别为0.232±0.023、0.172±0.042、0.261±0.044、0.122±0.011(1/h)。在低、中、高3种不同浓度下,A771726全肠段的吸收速率常数分别为0.712±0.094、0.719±0.106、0.703±0.143(1/h),差异无显著性。结论A771726在大鼠各肠段均有吸收,其吸收机制为被动扩散,吸收动力学为一级吸收。Objective To investigate the absorption kinetics of A771726 at different intestine segments in rats. Methods The intestine in rats was cannulated in stiu for recirculation. UV and HPLC were used to determine the concentrations of phenol red and A771726, respectively. Results The absorbed rates of A771726 were 36. 0%± 2. 1% ,27.5% ±4. 2% ,38. 1% ±5.1% ,22. 5% ±2. 3% ,and the absorption rate constants （Ka） were 0. 232± 0. 023,0. 172 ± 0. 042,0. 261 ± 0. 044,0. 122 ± 0. 011 （ 1/h） respectively in duodenum, jejunum, ileum and colon. The absorption rate constants of A771726 were 0. 712 ± 0. 094,0. 719 ±0. 106 and 0. 703 ± 0. 143 （1/h）, respectively at different concentrations including low, medium, high concentration. Conclusion A771726 is absorbed in all intestine segments of rats with the passive transport mechanism and first order kinetics.

关 键 词：异嚼 唑类/药代动力学 色谱法 高压液相 分光光 度法 紫外线 肠吸收 

分 类 号：R969.1[医药卫生—药理学] R916.4[医药卫生—药学]