阿是止泻胶囊治疗甲状腺功能亢进性腹泻的体外抗菌实验研究  

In vitro Antibacterial Effect by Asi-antidiarrheal Capsule:An Experimental Study

作　　者：成志锋[1] 张瑛琦[2] 郭敏[2] 乔国芬[3] 

机构地区：[1]哈尔滨工业大学生命科学系 [2]哈尔滨医科大学附属第四医院内分泌科,黑龙江哈尔滨150001 [3]哈尔滨医科大学药学院,黑龙江哈尔滨150086

出　　处：《中华医院感染学杂志》2008年第6期768-769,873,共3页Chinese Journal of Nosocomiology

摘　　要：目的研究阿是止泻胶囊治疗甲状腺功能亢进性腹泻的体外抗菌作用。方法采用试管内药液稀释法测定;受试药物用自拟方中药阿是止泻胶囊,阳性对照药物用复方地芬诺酯(苯乙呱啶)片;分别对该两种药物进行8种菌株的体外抗菌实验。结果阿是止泻胶囊对痢疾志贺菌、金黄色葡萄球菌、肺炎链球菌有较强的抑菌作用(MIC值均为31.25 mg/L);复方苯乙呱啶片仅对金黄色葡萄球菌、肺炎链球菌、酿脓链球菌、痢疾志贺菌有较小的抑菌作用(MIC值均为0.25 mg/L)。结论阿是止泻胶囊不仅可用于治疗甲状腺功能亢进性腹泻,还有较强的抗菌作用,为今后用于治疗感染性腹泻提供了药效学实验依据。OBJECTIVE To investigate the in vitro antibacterial effect of Asi-antidiarrheal capsule a Chinese herbal compound on hyperthyroid diarrhea. METHODS It was determined by drug dilution method in test tube to determine Asi-antidiarrhea capsule. The compound positive control drug was diphenoxylate co. We made in vitro antibacterial test with 8 kinds of bacteria respectively. RESULTS Asi-antidiarrhea capsule had powerfully bacteriostatic action on Shigella dysenteriae, Staphylococcus aureus and Streptococcus pneumoniae （MIC 31.25 mg/L）. But diphenoxylate co contrally was less effective on S. aureus, Str. pneumoniae, Str. pyogenes and Sh. dysenteriae（MIC O. 25 mg/L）. CONCLUSIONS Asi-antidiarrhea capsule can be used to hyperthyroid diarrhea. Meanwhile, it has powerfully antibacterial effect. It provides evidence of pharmacodynamics for healing infectious diarrhea in the future.

关 键 词：阿是止泻胶囊 甲状腺功能亢进性腹泻 体外抗菌实验 

分 类 号：R282.7[医药卫生—中药学]