过敏性紫癜患儿食物不耐受检测情况分析  

Analysis of Food Intolerance Test in Children with Henoch-Schonlein Purpura

作　　者：朱静[1] 毕玉娜[1] 孙建新[1] 李晓忠[1] 

机构地区：[1]苏州大学附属儿童医院肾脏免疫科,江苏苏州215003

出　　处：《实用儿科临床杂志》2008年第9期675-676,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的通过对过敏性紫癜（HSP）患儿进行食物不耐受检测,了解患儿食物过敏情况。方法选取苏州大学附属儿童医院2006年12月-2007年5月收住的HSP患儿74例。男40例,女34例;年龄7.6（3～14）岁。抽取HSP患儿静脉血2mL,分离血清,采用酶联免疫法按试剂盒说明书检测患儿血清14种食物变应原IgG水平。食物变应原特异性IgG抗体水平分为4级：0：IgG〈0.05U/L为阴性,＋：IgG0.05～0.10U/L为轻度敏感,＋＋：IgG0.10～0.20U/L为中度敏感,＋＋＋：IgG〉0.20U/L为重度敏感。结果74例HSP患儿进行食物不耐受检测,其中57例结果阳性,阳性率达77.0%。1种食物特异性IgG升高者24例（42.1%）,2种食物特异性IgG升高者16例（28.1%）,3种食物特异性IgG升高者12例（21.1%）,4种及以上食物特异性IgG升高者5例（8.7%）。食物特异性IgG升高以鸡蛋93.0%最高,其次是牛奶26.3%,大豆15.8%,西红柿14.0%,小麦、鳕鱼各12.3%,虾、蟹各8.8%,牛肉3.5%,玉米、大米各1.8%。结论食物不耐受检测可作为HSP患儿寻找食物过敏原的一个有效途径,并可指导HSP患儿的饮食。Objective To understand the information of food hypersensitivity of children with Henoch - Schonlein purpura （HSP） by food intolerance test. Methods Seventy - four children （40 boys and 34 girls ; aged from 3 to 14） with HSP who were hospitalized in our hospital from Dec. 2006 to May 2007 were chosen. Two mils venous blood was collected from each object,separated serum. Enzymelinked immunosorbent assay method was applied to detect the serum concentration of 14 kinds food allergen IgG in 74 children with HSP. The concentration of food allergen IgG was divided into 4 levels ： 0 （ IgG 〈 0.05 U/L, negative）, ＋ （ IgG 0.05 - 0. 10 U/L, mild allergy）, ＋ ＋ （ IgG 0. 10 - 0.20 U/L, moderate allergy） , ＋ ＋ ＋ （ IgG 〉 0.20 U/L, servious allergy）. Results The positive rate was 77.0% in 74 cases with HSP. One type of food allergen specific IgG increased in 24 cases（42.1% ） ,2 types of antibodies increased in 16 cases （28.1% ）, 3 types of antibodies increased in 12 cases（21.1% ）. Four or more types of antibodies increased in 5 cases （8.7 % ）. The positive rates of 14 food allergen IgG were as follow：egg 93.0% ,milk 26.3% ,soybean 15.8% ,tomato 14.0% ,wheat 12.3% ,llng 12.3% ,shrimp 8.8% ,crab 8.8% ,beef 3.5% ,corn 1.8% ,rice 1.8%. Conclusion Food intolerance test is a useful method for children with HSP to find food allergen and guideline for diet of these children.

关 键 词：食物不耐受 紫癜 过敏性 儿童 

分 类 号：R725.5[医药卫生—儿科]