轮状病毒肠炎患儿血锌水平变化及补锌治疗效果  

Changes of Serum Zinc Level of Rotaviral Enteritis in Children and Therapeutic Effect of Zinc

作　　者：康春华[1] 丘小汕[2] 华莉[3] 黄焕葵[3] 

机构地区：[1]东莞市人民医院儿科,广东东莞523018 [2]中山大学附属第一医院儿科,广州510080 [3]东莞市人民医院亚健康科,广东东莞523018

出　　处：《实用儿科临床杂志》2008年第10期765-766,770,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨轮状病毒(RV)肠炎患儿血清锌水平变化及补锌治疗对RV肠炎的疗效。方法收集1183例健康儿童(健康对照组)空腹静脉血清,按年龄分组测定血清锌水平,记录并经统计学处理,将该值作为东莞地区该年龄段儿童血锌正常值。收集近2a因急性水样腹泻起病2d内在门诊经大便RV抗原检测阳性确诊为RV肠炎的143例患儿,随机分为补锌治疗组72例,常规治疗组71例。检测二组患儿血锌水平。常规治疗组患儿给予蒙脱石散剂及补液等常规治疗;补锌治疗组在常规治疗的基础上口服葡萄糖酸锌片20mg/d(6个月以下者10mg/d),连续治疗14d。检测治疗后血锌水平。结果RV肠炎患儿血锌水平明显低于本地区同龄健康儿童血锌水平,差异有显著性意义(P<0.01)。补锌治疗组总有效率95.8%,常规治疗组为81.6%,二组差异有显著性意义(χ2=18.88P<0.01)。补锌治疗组患儿治疗后血锌值与健康对照组比较差异无显著性意义(P>0.05)。结论RV肠炎患儿血清锌水平明显降低,在腹泻常规治疗的基础上佐以补锌治疗对提高RV肠炎的疗效有良好的作用。WHO推荐补锌的剂量和疗程同样适合中国小儿RV肠炎的辅助治疗。Objective To explore the change of serum zinc level of children with rotavirus （RV） enteritis and efficacy of zinc supple- mentation on children with rotaviral enteritis. Methods One thousand one hundred and eighty - three healthy children were enrolled in this study, who were divided into different groups, and the zinc levels of children in every different age group were detected. These levels were used as normal levels of children in Dongguan district. One hundred and forty - three diarrhea patients in this 2 years were enrolled. Confirmed diagnosis was depended on the RV test in patients＇ stool. The children with diarrhea were randomly divided into zinc treatment group （n = 72 ） and conventional therapy group （n = 71 ）. The serum zinc levels in RV enteritis was analyzed. The patients in conventional therapy group were received diarrhea conventional therapy inchuded smectite and fluid infusion and so on;in addition to diarrhea conventional therapy, zinc gluconate 20 mg/d （10 mg/d below 6 months of age） for successive 14 days were given the patientsin zinc treatment group. The different efficacy of the 2 groups and the changes of serum zinc in treatment group were analyzed. Results Compared with normal children, the ones suffering from RV enteritis had lower serum zinc level（ P 〈 0.01 ）. The total efficacy of zinc treatment group （95.8 % ） , was much better than that of conventional therapy group （81.6%） ,there was a significant difference （Χ^2 = 18.88 P 〈 0.01 ）. After zinc treatment, serum zinc in treatment group returned to normal level（P 〉 0.05 ）. Conclusions The ones suffering from RV enteritis have lower serum zinc level. In addition to diarrhea conventional therapy,giving zinc treatment has better effect on enhancing curative effect of RV enteritis. On the other hand, the suggestion of zinc supplement made by WHO is also suitable for Chinese children.

关 键 词：锌 儿童 轮状病毒 肠炎 

分 类 号：R725.1[医药卫生—儿科]