接触低浓度苯系混合物作业工人细胞微核率及染色体断裂率的观察  

THE RESEARCH ON THE FREQUENCES OF MICRONUCLI AND CHROMOSOME BREAKS OF THE MIXTURE BENZENE WORKERS.

作　　者：赵国华[1] 董定龙[1] 王德启 艾晓清 浦卫东 胡宝友[1] 穆庆梅 李学东 

机构地区：[1]大庆职工医学院优生遗传研究所

出　　处：《现代预防医学》1997年第4期394-395,402,共3页Modern Preventive Medicine

摘　　要：目的：探讨混合苯对作业工人遗传物质是否有损害。方法：采用微核技术对混合苯作业工人４１人进行微核及染色体断裂率观察。结果：工人的微核率、微核细胞率及染色体断裂三项指标分别为１４．４９‰、１２．９７‰、１．７５％均明显高于对照组（Ｐ＜０．０１）。在岗年限６年以上组三项指标均高于在岗年限５年以下组（Ｐ＜０．０１）。结论：混合苯对作业工人遗传物质具有损害作用。其损害程度随着接触时间呈递增趋势。bjective:To study whether Mixture Benzene can damage the worker genetic materials.Methods:Using the micronucleus technique we observed 41 Mixture Benzene workers frequences of micronucli and chromosme breaks.Results:Mixture Benzene workers micronucleus rate,micronucleus cell and chromosome break rate are 1449‰、1297‰、175% and are all significantly higher than control group(P<001).The three data of the group working more than 6 years are higher than that of the group working less than 5 years(P<001)Conelusion:Acrylonitrile can damage workers genetic materials and the degree of the damage increases with working years.

关 键 词：混合苯 遗传物质 损害 工业毒物 微核率 

分 类 号：R994.3[医药卫生—毒理学]