高山红景天多糖对病毒感染大鼠心肌细胞的抑制作用  

Inhibition of polysaccharde extracted from rhodiola sachalinensis A. bor on myocardial cells infected by cox B3 virus

作　　者：孙非[1,2] 于起福[1,2] 孙寒[1,2] 吕才模 杨景旭 

机构地区：[1]白求恩医科大学应用基础医学研究所病毒研究室 [2]空军乌鲁木齐医院内科

出　　处：《中国药理学通报》1997年第6期525-528,共4页Chinese Pharmacological Bulletin

基　　金：吉林省科委基金

摘　　要：目的：观察高山红景天多糖对柯萨奇Ｂ３病毒感染ＳＤ大鼠心肌细胞的抑制作用。方法：采用原代培养乳鼠心肌细胞的方法，建立实验性病毒性心肌炎模型。结果：高山红景天多糖能明显的抑制体外培养心肌细胞在受到柯萨奇Ｂ３病毒感染后导致的心肌酶释放；显著降低病毒在心肌细胞中的增殖量；其半数有效抑制浓度为１５０ｍｇ·Ｌ－１；有效浓度平均抑制率为７１．３％。结论：高山红景天多糖对在ＳＤ大鼠心肌细胞内增殖的柯萨奇Ｂ３病毒具有一定的抑制作用。AIM: To observe the inhibitive effect of polysaccharide extracted from Rhodiola Sachalinensis A. Bor on myocardial cells infected by cox B3 virus. METHOD: To establish an experimental model of viral myocarditis through the culture of cardiac cells of newborn SD rats. RESULTS: The polysaccharide could inhibit the release of enzymes from myocardial cells which were infected by coxsackie B3 virus in vitro; and decrease obviously the reproduction of virus in myocardial cells; the half inhibitive concentration was 150 mg·L-1; the average effective inhibiting rate was 713%. CONCLUSION: The polysaccharide extracted from Rhodiola Sachalinensis A. Bor could inhibit the reproduction of coxsackie B3 virus in myocardial cells of SD rats.

关 键 词：高山红景天多糖 柯萨奇B3病毒 心肌细胞 药理 

分 类 号：R284.1[医药卫生—中药学] R978.7[医药卫生—中医学]