关附乙酯对大鼠离体心房肌的影响  

Effect of diacetyl guanfu base A on isolated rat atrial muscle

作　　者：丁吉新 张世玲[1,2] 王如斌[1,2] 

机构地区：[1]山东省新药药理研究中心 [2]山东医科大学药学系药理教研室

出　　处：《中国药理学通报》1997年第6期541-544,共4页Chinese Pharmacological Bulletin

摘　　要：目的：研究关附乙酯（ＤＧＦＡ）对大鼠离体心房肌的作用。方法：常规离体器官实验法。结果：ＤＧＦＡ降低了大鼠离体右心房肌的收缩力（Ｐ＜０．０５）并呈浓度依赖性，对右心房的自律性无明显影响；４μｍｏｌ·Ｌ－１ＤＧＦＡ能显著抑制肾上腺素诱发的大鼠离体左房肌的自律性，药前肾上腺素（ＡＤ）的浓度为７．９２±２．７５μｍｏｌ·Ｌ－１，药后１０ｍｉｎ，ＡＤ的浓度升至１６．７７±６．１２μｍｏｌ·Ｌ－１（ｎ＝６，Ｐ＜０．０１）；４μｍｏｌ·Ｌ－１ＤＧＦＡ在药后１０ｍｉｎ，使大鼠离体左房的功能性不应期（ＦＲＰ），由药前的１３０±１２．６ｍｓ延长至１５０±１２．６ｍｓ（ｎ＝６，Ｐ＜０．０５），但对离体大鼠左房肌的兴奋性无明显影响。结论：ＤＧＦＡ的抗心律失常作用可能与其抑制Ｎａ＋、Ｃａ２＋跨膜转运有关。AIM: The effects of Diacetyl guanfu base A(DGFA) were investigated. METHODS: The contractility, automaticity, functional refractory period(FRP) and excitability of DGFA on isolated rat atrial muscle were studied according to the regular methods. RESULTS: DGFA could depress the contractility of isolated rat right atria in a concentrationmanner, but had little effect on its spontaneous rate compared with vehicle; DGFA (4 μmol·L-1) could remarkably depress the automaticity of isolated rat left atria induced by adrenaline(AD), the concentration of AD rose from 792±275 μmol·L-1 to 1677±612 μmol·L-1 (n=6,P<001); the functional refractory period (FRP) of preparation was prolonged from 130±126 ms to 150±126 ms, (n=6,P<005); but had little effect on the excitability of preparation. CONCLUSION: The antiarrhythmic mechanism of DGFA may be related to its inhibition on Na+ and Ca2+ transmembrane influx.

关 键 词：DGFA 心房肌 功能性不应期 自律性 药理 

分 类 号：R284.1[医药卫生—中药学] R972.2[医药卫生—中医学]