超氧化物歧化酶对实验性骨折愈合的影响  

Effect of superoxide dismutase for experimental fracture healing

作　　者：邓廉夫[1,2,3] 

机构地区：[1]济宁医学院药理教研室 [2]上海医药工业研究院毒理学研究室 [3]上海市伤骨科研究所

出　　处：《中国药理学通报》1997年第6期544-547,共4页Chinese Pharmacological Bulletin

摘　　要：目的：探讨超氧化物歧化酶（ＳＯＤ）对实验性骨折愈合的作用。方法：应用３Ｈ－脯氨酸和４５Ｃａ－氯化钙无载体放射性核素体内示踪法，检测了ＳＯＤ对实验性骨折过程中基质形成与钙化的影响，并观察了骨痂组织细胞的形态学变化。结果：ＳＯＤ使３Ｈ－脯氨酸和４５Ｃａ－氯化钙参入早期骨痂的量增加（与对照组相比，Ｐ＜０．０１），４５Ｃａ／３Ｈ的比率提高迅速。早期骨痂内毛细血管含量增加；软骨细胞、成纤维细胞功能活跃，基质钙化迅速、完全，骨性骨痂发生早。结论：ＳＯＤ可作为促进骨折愈合的辅助疗法。AIM: To investigate the effects of superoxide dismutase (SOD) on fracture healing. METHODS: Ralioisotop tracers techology (e.g. intraperitoneal 3Hproline and 45Cacalcium chloride carrierfree solution) was used to detecte the effects of SOD on formation and calcification of collagenous and electrosmicroscope used to examin the histologic and ultrastructural features of callus. RESULTS: ① The amount of 3H and 45Ca was increased, and the 45Ca/3H ratio increased more rapidly after using SOD in the calls; ② Capillary formation was abundent ,the osteoblasts and fibroblasts were more active in forming bony tissues; ③ Mineralization of collagenous matrix was accelerated and osification process was shorten during the fracture healing. CONCLUSIONS: It is suggested that the healing of experimental fracture was expedited as a result of treatment with SOD.

关 键 词：超氧化物歧化酶 氧自由基 骨折愈合 药理 

分 类 号：R683[医药卫生—骨科学] R965.2[医药卫生—外科学]