山茱萸对延长大鼠异位心脏移植存活的作用  

CORNUS OFFICINALIS SIGNIFICANTLY PROLONGS THE SURVIVALS OF HETEROTOPIC CARDIAC ALLOGRAFTS IN RATS

作　　者：唐功耀 赵武述 

出　　处：《中日友好医院学报》1997年第4期287-290,共4页Journal of China-Japan Friendship Hospital

摘　　要：目的：观察山茱萸水煎剂对大鼠异位移植心脏排异的抑制作用。方法：异位移植心脏的大鼠分成４组：Ⅰ组为对照，喂生理盐水；Ⅱ组喂山茱萸水煎剂２０ｇ／（ｋｇ·ｄ）；Ⅲ组喂环孢菌素Ａ（ＣｓＡ）５ｍｇ／（ｋｇ·ｄ）；Ⅳ组喂ＣｓＡ５ｍｇ／（ｋｇ·ｄ）和山茱萸水煎剂２０ｇ／（ｋｇ·ｄ）。结果：Ⅰ组（ｎ＝１３）移植心脏存活１３７±３７ｄ；Ⅱ组（ｎ＝１０）存活２８５±６２ｄ，另有２只移植心脏存活＞１ａ；Ⅲ组（ｎ＝７）存活４０１±６９ｄ，另有１只存活５个月；Ⅳ组（ｎ＝７）存活４９７±８０ｄ，另有１只存活５个月，１只存活＞８个月。Ⅱ组与Ⅰ组间、Ⅳ组与Ⅱ组间均有非常显著差异（Ｐ＜００１）；Ⅳ组与Ⅲ组间有显著差异（Ｐ＜００５）。结论：山茱萸水煎剂能抑制排斥，显著延长大鼠异位移植心脏存活；山茱萸与ＣｓＡ联合应用比单用ＣｓＡ或山茱萸效果更好。Objective:To observe the effect of Cornus officinalis on the survival of heterotopic cardiac allografts in rats.Methods:46 recipient rats were randomly divided into 4 groups after heterotopic cardiac transplantation.The rats in different groups were orally administrated saline solution,Cornus officinalis decoction equivalent to 20 g/(kg·d),cyclosporine A(CsA) 5 mg/(kg·d) and combination of both,separately.Results:The mean survival time in control group( n =13)was 13 7±3 7 days,28 5±6 2 days in Cornus officinalis group( n =10),40 1±6 9 days in CsA group( n =7) and 49 7±8 0 days in combination group( n =7).The difference between Cornus officinals group and the control group,or between the combination group and Cornus officinalis group was very significant, P <0 05.In addition,in Cornus officinalis group there were 2 rats which allografts survived for 1 year,one rat over 5 months in CsA group and two rats in the combination group beyond 5 or 8 months,while no long term survivor in the control group.Conclusion:①Cornus officinalis can effectively suppress the rejection of rat cardiac transplantation and significantly prolong survival time;②the combination of Cornus officinalis and CsA is more effective than both alone.

关 键 词：药 中草 免疫抑制 心脏移植 大鼠 

分 类 号：R285.5[医药卫生—中药学] R229[医药卫生—中医学]