妊娠期人乳头瘤病毒的感染状况及母婴传播的研究  

A study of human papillomavirus infection during pregnaney and transmission of virus to fetus.

作　　者：邓东锐[1] 闻良珍[1] 王志新[1] 曾万江[1] 凌霞珍[1] 

机构地区：[1]同济医科大学附属同济医院妇产科

出　　处：《中华实验和临床病毒学杂志》1997年第4期369-371,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：国家八五科技攻关基金

摘　　要：应用聚合酶链反应检测孕妇尖锐湿疣（ＣＡ）组织、无ＣＡ孕妇宫颈分泌物、外周血及羊水、新生儿咽分泌物、脐血中人乳头瘤病毒（ＨＰＶ）感染及母婴传播。结果表明：ＣＡ组织中ＨＰＶＤＮＡ阳性率为９０．３２％，以ＨＰＶ６／１１型为主；无ＣＡ孕妇宫颈分泌物中ＨＰＶＤＮＡ阳性率为３５．７１％，以ＨＰＶ１６／１８型为主；孕妇血中ＨＰＶＤＮＡ阳性率为５７．６９％；母婴间经产道垂直传播率为４４．４４％，血性经胎盘传播传播率为６０％。说明ＨＰＶ不仅存在于ＣＡ组织中，还存在于无ＣＡ孕妇生殖道及外周血中，母婴间传播途径除产道外。To study the human papillomavirus (HPV) infection during pregnancy and transmission of virus to fetus, samples such as, cervical secretion, peripheral blood, amniotic fluid, neonatal umbilical blood from 96 women with normal pregnancy were screened for HPV DNA by polymerase chain reaction (PCR), and HPV DNA in condyloma acuminata tissues, amniotic fluid of 31 pregnant women were detected by PCR as well. The results showed HPV DNA positive rate of condyloma acuminata tissues was 92.32%, of cervical secretion in normal pregnant group, was 35.71%, of peripheral blood was 57.69%. The HPV DNA maternalfetus transmission rate was 44.44%, the transmission rate via placenta was 60%. It is concluded that HPV DNA can be found not only in condyloma acuminata tissues, but also in genital tract, peripheral blood of pregnant women, Besides the transmission route of genital tract, there is also the bloodplacenta route.

关 键 词：妊娠 人乳头瘤状病毒 感染 聚合酶链反应 

分 类 号：R714.251[医药卫生—妇产科学] R373.9[医药卫生—临床医学]