双(α-呋喃甲酸)氧钒与六味地黄丸联合使用对糖尿病大鼠抗氧化损伤作用的实验研究  

Experimental study of the anti-oxidative damage effects of Bis(α-furan carboxylato) oxovanadium combining Liuwe Dihuang Wan to diabetes mellitus rats

作　　者：冯莉[1] 徐秀梅[1] 张艳军[1] 谢明进[2] 阎世平[2] 范英昌[1] 

机构地区：[1]天津中医药大学,天津300193 [2]南开大学,天津300071

出　　处：《山东中医杂志》2008年第6期408-410,共3页Shandong Journal of Traditional Chinese Medicine

基　　金：天津市高等学校科技发展基金项目(编号:20050306);天津市卫生局中西医结合科研课题(编号:07011)

摘　　要：目的:观察双(α-呋喃甲酸)氧钒(VO-FA)与六味地黄丸联合使用对糖尿病大鼠抗氧化损伤的作用。方法:用四氧嘧啶诱发糖尿病大鼠模型,分别以高、低剂量VO-FA、六味地黄丸及高、低剂量VO-FA联合六味地黄丸治疗,并设立正常组和模型组作对照,治疗4周后,检测各组大鼠血糖及血清T-SOD、MDA值。结果:VO-FA高剂量组和六味地黄丸组治疗后,大鼠血糖值明显低于模型组(P<0.05,P<0.01),联合治疗组血糖值明显低于模型组(P<0.01);六味地黄丸组可增强血清T-SOD活性,降低MDA含量(P<0.05),联合治疗组可增强疗效,而VO-FA高、低剂量组对其影响无统计学意义。结论:VO-FA与六味地黄丸联合使用能降低血糖,提高糖尿病大鼠T-SOD活性,降低MDA含量,减轻氧化损伤。Objective： to observe the anti-oxidative damage effect of the Bis（α-furan carboxylato）oxovanadium（VO-FA）combining Liuwei Dihuang Wan（LW）to diabetic mellitus（DM） rats. Methods： supplying two different dose of VO-FA,LW and two combining group to the DM rats that is made by aIloxan, four weeks later, detecting the blood glucose,T-SOD and MDA. Results： the higher dosage of VO-FA and LW can decline blood glucose, the combining groups can improving this effects. LW group can enhance the activity of T-SOD and decline MDA. The combining group can reinforce this effect, but there isn＇t statistically significant of the two VO-FA groups. Conclusion： VO-FA combining LW can decline the blood glucose of the DM rats, and it can enhance the activity of T-SOD ,declining content of MDA, relieving the oxidative damage.

关 键 词：糖尿病 双(Α-呋喃甲酸)氧钒 六味地黄丸 抗氧化 实验研究 

分 类 号：R285.5[医药卫生—中药学]