局部注射地塞米松对桥本氏甲状腺炎患者的免疫学影响  

Immunological Changes in Hashimoto s Patients Treated with Local Injection of Dexamethason

作　　者：丁兢康 陆福履[2] 柳龙图[2] 王胜军[2] 许化溪[2] 

机构地区：[1]扬中市人民医院 [2]镇江医学院,镇江212001

出　　处：《上海免疫学杂志》1997年第6期371-373,共3页Shanghai Journal of Immunology

摘　　要：采用免疫学和生物化学等方法,比较了甲状腺局部注射地塞米松和口服甲状腺片两种疗法对桥本氏甲状腺炎患者甲状腺球蛋山抗体、 甲状腺微粒体抗体、 甲状腺形态和疗效的影响。结果显示:（1）局部注射地塞米松可明显降低甲状腺球蛋白抗体和甲状腺微粒体抗体水平,缩小甲状腺最大直径和面积,较口服甲状腺片疗效大、疗程短;（2）地塞米松可明显升高血清T3、T4水平和降低TSH水平;（3）局部注射地塞术松无副作用和不良反应。结论:局部注射地塞米松可替代口服甲状腺片治疗多种类型的桥本氏甲状腺炎患者。Two therapeutic approaches for dexamethasone treatment of Hashimoto's thyroiditis were compared with respect to their effects on immmunological changes, including serum levels of TgAb, TMAb, T3, T4 and TSH, in addition to thyroid morphology and therapy efficacy. It was demonstrated that, in comparison with conventional oral administration, local administration of Dexamethasone was superior in that 1) significantly decreased the serum levels of TgAb and TMAb, reduced the maximum diameter and surface of the thyroid, enhanced the efficacy and shorten the course of treatment, 2) significantly elevated T3, T4 levels and reduced TSH levels, 3) had no any adverse and side effects. We conclude that local injection of Dexamethasone may substitute for oral administration in the treatment of Hashimoto's thyroiditis.

关 键 词：甲状腺炎 地塞米松 桥本病 免疫学 

分 类 号：R581.403[医药卫生—内分泌]