降钙素基因相关肽控制性降压对大鼠脑组织中能量储备的影响  

Effects of controlled hypotension induced with human α-calcitonin gene-related peptide and sodium nitroprusside on cerebral energy store in rat

作　　者：张诗海[1] 曾邦雄[1] 金士翱[2] 

机构地区：[1]同济医科大学附属协和医院麻醉科,武汉市430022 [2]同济医科大学附属同济医院麻醉科

出　　处：《中华麻醉学杂志》1997年第12期728-730,共3页Chinese Journal of Anesthesiology

摘　　要：目的:探讨降钙素基因相关肽(α-hCGRP)和硝普钠控制性降压对脑组织中能量储备的影响,以比较两种药物应用于控制性降压的安全性。方法:20只SD大鼠分为α-hCGRP(C)组和硝普钠(S)组,两组动物分别静注0.001％α-hCGRP和0.01％硝普钠,使平均动脉压降至6.7kPa,并维持30分。用免疫荧光法测定两组动物降压前后脑组织中葡萄糖、乳酸以及储备能源ATP和磷酸肌酐的含量。结果:C组动物降压后脑组织中葡萄糖含量轻度升高,乳酸含量下降,ATP和磷酸肌酐的含量不变。S组动物降压后脑组织中葡萄糖含量轻度升高,乳酸含量显著升高,而ATP和磷酸肌酐的含量显著下降。结论:α-hCGRP应用于控制性降压可维持脑组织正常的能量储备,而硝普钠则引起脑组织储备能量被耗竭,因而α-hCGRP应用于控制性降压较硝普钠安全。Objective: To evaluate the safety of controlled hypotension produced by human α-calcitonin gene-related peptide(α-hCGRP)and sodium nitroprusside. Method: Twenty SD rats were randomly divided into α-hCGRP(C) and sodium nitroprusside(S) groups. Animals in group C were infused intravenously with 0.001％ α-hCGRP and those in group S with 0.01％ sodium nitroprusside. The mean blood pressure of rat was reduced to 6.7kPa and maintained for 30 min. Cerebral glucose,lactate,ATP, and phosphocreatine levels were measured at 0 and 30th min of hypotension. Result: Cerebral glucose level increased slightly,lactate level decreased significantly,ATP and phosphocreatine contents did not change in group C at 30th min of hypotension compared with those at 0 min of hypotension,respectively.Cerebral glucose level increased slightly,lactate concentration increased significantly,ATP and phosphocreatine contents decreased significantly in group S at 30th min of hypotension in comparison with those at 0 min of hypotension, respectively. Conclusion: Hypotension induced with alpha-hCGRP can maintain adequate cerebral oxygen supply,but with sodium nitroprusside may cause cerebral hypoxia.

关 键 词：降钙素 基因相关肽 硝普钠 降压 控制性降压 脑 

分 类 号：R972.4[医药卫生—药品]