新疆石河子地区125例B细胞性非霍奇金淋巴瘤的临床病理分析  

Studies on Clinical Pathology of 125 Cases B-cell non-Hodgkin's Lymphomas in Shihezi District of Xinjiang

作　　者：陈云昭[1] 李锋[1] 胡文浩[1] 李新霞[1] 刘春霞[1] 李洪安[1] 蒋金芳[1] 梁伟华[1] 

机构地区：[1]石河子大学医学院,新疆石河子832002

出　　处：《石河子大学学报（自然科学版）》2008年第2期137-142,共6页Journal of Shihezi University(Natural Science)

摘　　要：按照2001年世界卫生组织（WHO）淋巴瘤最新分类标准,分析和总结新疆石河子地区125例B细胞性非霍奇金淋巴瘤（B-NHL）的临床病理组织学及免疫组化特点,以探讨其在B-NHL的诊断和鉴别诊断中的价值。依据2001年WHO淋巴瘤新分类标准,运用临床病理形态观察及免疫组化对125例B-NHL进行临床病理研究。125例B-NHL患者发病平均年龄为47.6岁（1.5岁～81岁）,男女发病比例为2.4∶1。发生部位以淋巴结内为最常见（占60%）,其次为胃肠道（占20%）,还可见于涎腺等部位。按WHO分类,本组125例B-NHL确定了9个类型,未观察到淋巴结边缘区B细胞淋巴瘤、脾边缘区B细胞淋巴瘤、毛细胞白血病和B-前淋巴细胞白血病,其中最常见的3个类型依次是：弥漫大B细胞淋巴瘤（45例,36%）,滤泡淋巴瘤（40例,32%）,粘膜相关淋巴组织结外边缘区细胞淋巴瘤（22例,17.6%）。一些B-NHL的亚型有特异性免疫表型,对诊断和鉴别诊断有所帮助。病理形态是淋巴瘤诊断的基础,免疫表型在诊断和分型中起重要作用,二者与临床特征结合可使多数淋巴瘤得到明确诊断。To discuss the significance of diagnosis and differentiated diagnosis of B NHL with clinical pathology and immunohistochemistry feature by 125 cases B-cell non-Hodgkin＇s lymphomas（B-NHL） in Shihezi district of Xinjiang based on the new WHO classification of lymphoid neoplasms. 125 cases of B-NHL were consecutively selected from archives of the Department of pathology in Shihezi University School of Medicine. The clinicopathology and Immunohistochemistry of 125 cases B-NHL were studied based on the new WHO classification. The average age of 125 patients with B-NHL was 47.6 years（from 1.5 to 81 years）, B-NHL were more common in males than females （2：4： 1）. Most of the B-NHL （60%） arised in the lymph nodes, then gastrointestine （20%）, salivary glands and so on. 125 cases could be further classified into 9 subtypes according to morphological and immnophenotypical feature： among the 125 cases lymphomas,diffuse large B cell lymphoma, follicular lymphoma and extranodal marginal zone lymphoma were the more common subtypes, accounting for 36% （45 cases） ,32% （40 cases） and 17.6% （22 cases） of all cases,respectively. Some of B-NHL subtypes have special Immunohistochemical that can help for diagnosis and differentiated diagnosis. Morphologic observation is basic mathod to classify B cell NHL, immunohistochemical study also plays an important role in further subtyping. A combination of both modalities are sufficient for arriving at an accurate diagnosis in most cases of B-NHL.

关 键 词：WHO淋巴瘤分类 B-NHL 诊断 免疫表型 

分 类 号：S858.317.4[农业科学—临床兽医学] S858.23[农业科学—兽医学]