干扰素治疗小儿病毒性心肌炎的临床和免疫学观察  

Clinical and Immunological Observation on Interferon in Treatment of Infantile Viral Myocarditis

作　　者：李锋[1] 张立红[1] 田淑芝[1] 

机构地区：[1]河北省唐山职业技术学院临床医学系,河北唐山063000

出　　处：《医学综述》2008年第12期1915-1917,共3页Medical Recapitulate

摘　　要：目的探讨干扰素治疗小儿病毒性心肌炎的临床效果,并观察其对机体的免疫调节作用。方法63例病毒性心肌炎患儿随机分为实验组、对照组,均给予常规治疗,实验组加用干扰素。治疗前、后分别用流式细胞术检测外周血CD3+、CD4+和CD8+含量,用ELISA法检测血清IL-6、TNF-α和LDH1水平。结果实验组、常规组总有效率依次为89.3%和65.7%,二者比较差异有统计学意义(P<0.05);治疗后,两组患儿外周血CD3+和CD4+的含量、CD4+/CD8+比值增高,IL-6、LDH1、TNF-α和CD8+水平下降,治疗前后比较差异有统计学意义(P<0.05);与常规组治疗后相比,实验组患儿外周血CD3+和CD4+的含量、CD4+/CD8+比值增高,IL-6、LDH1、TNF-α和CD8+水平下降,差异亦有统计学意义(P<0.05)。结论干扰素治疗小儿病毒性心肌炎效果较好,且可改善机体的免疫状态。Objective To explore the clinical effects of interferon in treatment of infantile viral myocarditis,and its role of immunological regulation. Methods Sixty-three children with viral myocarditis were divided into experimental group and control groups ,both of which were treated with conventional therapy, and interferon was added to the experimental group. The contents of CD3^＋ 、CD4^＋ and CD8^＋ were detected by flow cytometry arid the levels of IL-6, TNF-α and LDH1 were detected with ELISA. Results The total effective rates of experimental and control groups were 89.3 % and 65.7% with significant difference （ P 〈 0. 05 ） ; After treatment, the contents of CD3^＋ arid CD4^＋ were increased, the ratios of CD4^＋ to CD8^＋ was increased, the levels of IL-6,LDH1 ,TNF-α and CD8^ ＋ were decreased in two groups（P 〈0.05）. Compared with control group,the contents of CD3^＋ and CD4^＋ were increased,the ratios of CD4^＋ to CD8^＋ was increased,the levels of IL-6 ,LDHl ,TNF-α and CD8^＋ were decreased in experimental groups after treatment, Statistical difference was also observed （ P 〈 0. 05 ）, Conclusion Interferon is effective in the treatment of infantile viral myocarditis, and it also can imorove the immune function.

关 键 词：病毒性心肌炎 干扰素 疗效 免疫 

分 类 号：R725.4[医药卫生—儿科]