乌司他丁治疗急性呼吸窘迫综合征临床研究  

Clinical study on therapy of acute respiratory distress syndrome with ulinastatin

作　　者：欧书钦[1] 马渝[1] 文玉明[1] 陶杨[1] 

机构地区：[1]重庆市急救医疗中心ICU,400014

出　　处：《重庆医学》2008年第12期1336-1337,共2页Chongqing medicine

摘　　要：目的评价乌司他丁在急性呼吸窘迫综合征(ARDS)患者中的治疗作用。方法36例ARDS患者随机分为实验组(n=18)和对照组(n=18),观察比较两组患者治疗前后血气指标改变、急性生理和慢性健康评分(APACHEⅡ评分)变化及病死率差异。结果实验组患者的动脉血气指标、APACHEⅡ评分的改善率均明显优于对照组,病死率亦明显低于对照组。结论乌司他丁能显著改善ARDS患者的血气指标及APACHEⅡ评分,预防多器官窘迫综合征(MODS)发生,并明显降低ARDS患者的病死率。Objective To evaluate the effect of ulinastatin on the therapy of acute respiratory distress syndrome（ARDS）. Methods Thirty-six patients with ARDS were randomly divided into experimental group（18 cases） and control group（18 cases）. We observed the change of the parameters of arterial blood gas, acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ ） score and mortality between the two groups, before and after treatment. Results The parameters of arterial blood gas, APACHE Ⅱ score were obviously superior to those of the control group. The mortality in the experimental group was significantly lower than that in the control group. Conclusion Ulinastatin can obviously improve the parameters of arterial blood gas,acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ ）score of the patients with ARDS. It also has obvious therapeutis effect on the prevention and cure of multiorgems distress syndrome（MODS） and decreasing the mortality of the patients with ARDS.

关 键 词：乌司他丁 急性呼吸窘迫综合征 多器官功能障碍综合征 病死率 

分 类 号：R563.8[医药卫生—呼吸系统] R974[医药卫生—内科学]