辅酶Q_(10)的合成  

Synthesis of Coenzyme Q_(10)

作　　者：杨运泉[1] 王威燕[1] 陈田[1] 罗和安[1] 周国平[1] 刘文英[1] 

机构地区：[1]湘潭大学化工学院,湖南湘潭411105

出　　处：《精细化工》2008年第6期583-586,共4页Fine Chemicals

基　　金：湖南省科技厅科技攻关项目(04FJ4116)~~

摘　　要：以还原型辅酶Q0(氢醌,Ⅳ)为母环,杂多酸为催化剂,与末端羟基取代的异戊二烯单元—(E)-1-苯磺酰基-2-甲基-4-羟基-2-丁烯(Ⅲ)进行偶联反应,溴苄酚羟基保护,制得6-(4-苯磺酰基-3-甲基-2-丁烯)-基-2,3-二甲氧基-5-甲基氢醌双苄醚(Ⅴ),收率75.0%,Ⅴ再与茄尼基溴(Ⅵ)偶联后制得接砜产物(Ⅶ),收率45.0%,Ⅶ经钠还原脱除苯磺酰基、硝酸铈铵氧化制得辅酶Q10(Ⅰ),收率30%。中间体与产物经测熔点、1HNMR和FTIR分析鉴定和确证结构。6-（ 4-Phenylsulfonyl-3-methyl-2-butenyl ）-2, 3-dimethoxy-5-methylhydroquinone-O, O′- dibenzyl ether （ Ⅰ ） was synthesized in 75% yield by coupling reaction between 2,3-dimethoxy-5- methyl-l, 4-hydroquinone and （ E ）-1-phenylsulfonyl-2-methyl-4-hydroxy-2-butene employing heteropoly-acid as catalyst. The target product coenzyme Q10 was synthesized in 30% yield by coupling reaction between Ⅰ and solanesyl bromide followed by reduction and oxidation of the corresponding intermediates. Structures of the target product and all intermediates are confirmed by IR and ^1HNMR.

关 键 词：辅酶Q10 侧链延长法 辅酶Q0 

分 类 号：TQ244.6[化学工程—有机化工]