大花鸡肉参的化学成分研究  

Studies on chemical constituents of Incarvillea mairei var.granditlora(Wehrhahn) Grierson

作　　者：苏永庆[1] 沈云亨[1] 张卫东[1] 

机构地区：[1]第二军医大学天然药物化学教研室

出　　处：《药学实践杂志》2008年第3期166-168,171,共4页Journal of Pharmaceutical Practice

基　　金：国家"863"计划(2006AA02Z338);中国博士后科学基金(20070410711)

摘　　要：目的:研究紫葳科角蒿属植物大花鸡肉参的化学成分。方法:利用硅胶色谱柱,制备薄层色谱和葡聚糖凝胶Sephadex LH-20柱纯化,硅胶柱色谱进行分离纯化,通过理化常数和光谱分析鉴定化合物的结构。结果:从大花鸡肉参的乙醇提取物中分离并鉴定了12个化合物的结构,分别是:邻-羟基苯甲酸(O-Hydroxybenzoic acid)、棕榈酸(Palmitic acid)、正二十六烷酸(Hexacosanoic acid)、β-谷甾醇(β-Sitosterol)、β-胡萝卜苷(Daucosterol)、齐墩果酸(Oleanolic acid)、乌苏酸(Ursolic acid)、槲皮素(Quercetin)、槲皮苷(Vincetoxicosi-de B)、对羟基苯甲酸(p-Hydroxy benzoic acid)、3-甲氧基-4-羟基苯甲酸(3-Methoxy 4-hydroxy-benzoic acid)、豆甾醇(Stigmasterol)。结论:化合物1-12均为首次从该植物中分离得到。Objective： To study the chemical constituents of Incarvillea mairei var. granditlora （Wehrhahn） Grierson. Methods： Isolation and purification were carried out by macroporous absorption resin and silica gel column chromatography, and twelve compounds were identified by spectral and chemical methods. Results：Twelve compounds were obtained from alcohol extract and were determined as o-hydroxy benzoic acid, palmitic acid, hexacosanoic acid, β-sitosterol, daucosterol, oleanolic acid, ursolic acid, quercetin, vincetoxicoside B ,p-hdroxy benzoic acid,3-mthoxy 4-hydroxy-benzoic acid, sgmasterol. Conclusion：All of 12 compounds were obtained from the plant for the first time.

关 键 词：紫葳科角蒿属 大花鸡肉参 化学成分 提取方法 

分 类 号：R931.71[医药卫生—生药学]