凝血VII因子IVS7基因多态性与深静脉血栓形成的相关性研究  

Related Study on IVS7 Polymorphism of the Coagulation Factor VII Gene with Deep Venous Thrombosis

作　　者：黄象男[1] 郑红[2] 臧新[1] 杨冬之[1] 贺颖[2] 

机构地区：[1]郑州大学生物工程系 [2]郑州大学基础医学院细胞生物学与医学遗传学教研室,河南郑州450052

出　　处：《河南职工医学院学报》2008年第3期215-216,225,共3页Journal of Henan Medical College For Staff and Workers

基　　金：河南省高校杰出人才创新工程基金资助(2005KYCX02);河南省杰出青年科学基金资助(0612001300);河南省科委攻关项目资助(0624410049)

摘　　要：目的探讨凝血因子VII基因IVS7多态性与河南汉族人群深静脉血栓形成(DVT)的相关关系。方法运用PCR-RFLP方法对103例DVT患者和250例健康对照进行FVII基因IVS7多态性的分析,并进行基因型频率与等位基因频率的比较。结果在IVS7多态性中,H7等位基因频率在DVT组和对照组之间存在显著性差异(P<0.05),并在国内首次发现H4等位基因。结论H7等位基因可能是河南汉族人群深静脉血栓发病的遗传性保护因子,IVS7多态性存在种族和地域差异。Objective To study the association of ⅣS7 polymorphism of the coagulation factor Ⅶ gene with deep venous thrombosis in Han population of Henan Province in China. Methods 103 cases of deep venous thrombosis and 250 healthy subjects （control group） were recruited in the study. The ⅣS7 polymorphisms of the coagulation factor Ⅶ（FVⅡ） gene were detected by PCR-RFLP. Results The distribution of H7 allele in ⅣS7 had significant differences between the DVT group and control group. Novel H4 allele of FVⅡ ⅣS7 was first found in China. Conclusion The H7 allele of ⅣS7 polymorphisms of the factor Ⅶ gene may be a protective genetic factor against deep venous thrombosis in Han population of Henan Province. The prevalence of gene mutation of ⅣS7 varies with different ethnic group or geographic regions.

关 键 词：血栓形成 凝血因子Ⅶ 基因多态性 

分 类 号：R593.2[医药卫生—内科学]