川白芷总香豆素治疗偏头痛的部分药效学实验研究  

Study on the Pharmacodynamics of Total Coumarin of Radix Angelicae Dahuricae in Treating Migraine

作　　者：秦旭华[1] 李祖伦[1] 朱果夫[1] 饶波[1] 王瑶[1] 谭叶楠[1] 张伟[1] 

机构地区：[1]成都中医药大学药学院中药教研室,四川成都610075

出　　处：《四川中医》2008年第6期4-6,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：四川省科技厅攻关项目(编号:2006C08-76)

摘　　要：目的:研究川白芷总香豆素的镇痛作用及对偏头痛模型大鼠的影响,考察川白芷总香豆素对偏头痛的治疗作用。方法:镇痛实验采用热板法和醋酸扭体法在小鼠上进行;偏头痛药效实验选用硝酸甘油致实验性偏头痛模型大鼠进行。结果:①川白芷总香豆素高剂量组(2.62g/kg)、中剂量组(1.31g/kg)、低剂量组(0.65g/kg)均具有明显的镇痛作用,以醋酸扭体法镇痛作用表现明显(P<0.05;P<0.01);②对硝酸甘油致实验性偏头痛模型大鼠的药效学实验显示,川白芷总香豆素高剂量组(2.62g/kg)、中剂量组(1.31g/kg)的模型动物耳红消失的时间明显缩短(P<0.05);挠头消失时间明显缩短(P<0.05);爬笼次数明显减少(P<0.05)。结论:川白芷总香豆素具有明显的镇痛作用,且对硝酸甘油所致实验性偏头痛大鼠模型表现出较好的治疗作用,提示白芷总香豆素对偏头痛有一定的治疗作用,可进一步开发和研究。Objective： To study the analgesic effect of total coumarin of Radix Angelicae dahuricae, and to investigate its effects on migraine model rats. Methods ： The methods of hot plate and acetic acid twisting were adopted in the research of analgesic effect. The model rats of migraine were induced by nitroglycerinum. Results ： （1） The total coumarin of Radix Angelice dahuricae had an obvious analgesic effect in high dosage group （2.62g/kg） ; middle dosage group （1.31g/kg） and low dosage group （0.65g/kg） . The analgesic effect was not obvious on rats treated with acetic acid twisting （ P 〈 0.05; P 〈 0.01 ）. （2） The experiments of therapeutical effect showed that the total coumarin of Radix Angelicae dahuricae could shorten the time of red ear and head scratching in migraine model rats （ P 〈 0.05 ）, and also reduce the number of climbing cage （ P 〈 0.05 ） ： Conclusion ： The total coumarin of Radix Angelicae dahuricae has an obvious analgesic effect, and shows a positive therapeutic effect in migraine model rats. This means that the total coumarin of Radix Angelicae dahuricae can be used to treat migraine. It is worth further researching and developing.

关 键 词：川白芷总香豆素 偏头痛 实验研究 

分 类 号：R285.5[医药卫生—中药学]