糖尿病肾病与糖尿病视网膜病变关系的研究  

The study of the relationship between the incidence and grade of diabetic nephropathy and diabetic retinopathy

作　　者：刘惠兰[1] 李国刚[1] 薛菲[1] 胡海英[1] 

机构地区：[1]首都医科大学附属复兴医院肾内科,北京100038

出　　处：《中国医师进修杂志》2008年第6期10-11,共2页Chinese Journal of Postgraduates of Medicine

摘　　要：目的研究糖尿病肾病（DN）与糖尿病视网膜病变（DR）发生的相关关系。方法选取2型糖尿病患者154例，散瞳后行眼底检查。同日测定血尿素氮、肌酐、糖化血红蛋白、血脂、血清白蛋白，同时留取8h尿液测定尿微量白蛋白，MDRD公式计算肾功能估算的肾小球滤过率（eGFR）。结果DN各组之间，DR各期的发病例数比较差异有统计学意义。对DR的相关分析结果表明，DR的损害程度与糖尿病病程、尿白蛋白排泄率、TC呈正相关（P〈0．01或〈0．05），与eGFR呈负相关（P〈0．01）。结论DR与DN二者的发病有高度正相关性，其损害程度有一定平行关系。Objective To investigate the relationship between the incidence and grade of diabetic nephropathy （DN） and diabetic retinopathy（DR） in patients with type 2 diabetes mellitus. Methods A total of 154 patients with type, 2 diabetes mellitus （80 males and 74 females） were investigated, ocular fundus were examined after mydriasis, at the same day, blood urea nitrogen, creatinine, glycosylated hemoglobin, blood fat, serum albumin were determined, the microalbuminuria and the glomerular filtration rate were performed. Results The incidences of DR with each stage were significantly different according to different DN stages. Univariate analyses revealed that the disorder of DR was positively correlated with the duration of diabetes, microalbuminuria, blood cholesterol （P〈 0.01 or 〈 0.05 ）, and negatively correlated with the glomerular filtration rate （P〈 0.01 ）. Conclusion The incidence of DN and DR has the highly concordance, and their lesions have some parallel relationship.

关 键 词：糖尿病 糖尿病肾病 糖尿病视网膜病变 

分 类 号：R587.2[医药卫生—内分泌] R587.1[医药卫生—内科学]