慢性乙型肝炎患者血小板减少相关因素及其数学模型的建立  

Research on the influential factors of the thrombocytopenia in patients with chronic type B hepafitis and the mathematical model

作　　者：谭斌[1] 何伟锋[1] 温帆渊[1] 许岸高[1] 

机构地区：[1]广东省惠州市中心人民医院消化内科肝病区,516001

出　　处：《中国医师进修杂志》2008年第6期20-22,共3页Chinese Journal of Postgraduates of Medicine

基　　金：广东省惠州市科技计划（44011120060309）

摘　　要：目的探讨慢性乙型肝炎患者血小板减少的发病机制。方法对76例慢性乙型肝炎和肝硬化血小板减少患者进行血清促血小板生成素（TPO）水平、巨核细胞（MK）计数、血小板相关免疫球蛋白G（PAIgG）、脾脏指数（SPI）、凝血酶原活动度（PTA）检查。结果多元线性逐步回归分析显示，Pt与血清TPO水平、MK计数、SPI、PTA相关（r值分别为0．450、0．521、-0．438、0．428，P〈0．05），所得数学模型：Pt=36．38＋0．23TPO-0．57SPI＋0．69MK，R^2=0．57，F=18．78，P〈0．01。结论血清TPO水平下降、骨髓巨核细胞系统抑制及脾功能亢进在慢性乙型肝炎患者血小板减少的发病机制中起重要作用。Objective To explore the pathogenesis of thrombocytopenia in chronic type B hepatitis. Methods The serum thrombopoietin （TPO） levels, bone marrow megakaryocyte （MK）count, platelet-associated immunoglobulin G （PAIgG）, splenic index （SPI）, prothrombin activity （ PTA）were measured in 76 chronic type B hepatitis patients with thrombocytopenia. Results The regression analysis revealed that the platelet count was correlated with parameters including the serum TPO levels, bone MK count, SPI and PTA （r was 0.450, 0.521, -0.438, 0.428 respectively, P 〈 0.05）. The regression equation was Pt = 36.38＋0.23 TPO-0.57 SPI＋0.69 MK, R^2 = 0.57, F = 18.78, P 〈 0.01. Conclusion It suggests that decline of thrombopoietin, myelosuppression and hypersplenism may contribute to thrombocytopenia in chronic type B hepatitis patients.

关 键 词：血小板生成素 巨核细胞 血小板减少 模型 理论 多因素分析 

分 类 号：R51[医药卫生—内科学]