白细胞介素12的生物学功能与药理学作用  

Biological function and pharmacologic effects of interleukin-12

作　　者：郑华宁[1] 甘慧[1] 周大兴[2] 窦桂芳[1] 

机构地区：[1]军事医学科学院输血研究所药代动力学重点实验室,北京100850 [2]浙江中医药大学药学院药理系,浙江杭州310053

出　　处：《国际药学研究杂志》2008年第3期194-197,共4页Journal of International Pharmaceutical Research

摘　　要：白细胞介素12(IL-12)是由巨噬细胞等抗原提呈细胞产生的细胞因子。IL-12对T细胞、自然杀伤细胞具有免疫调节作用,促进Th1介导的细胞免疫反应。研究证实,IL-12对小鼠的肿瘤和各种感染性疾病等有治疗作用。国内外学者采用不同的治疗途径及不同的联合方案进行了大量的尝试。本文对目前IL-12的生物学功能及药理学作用作一综述。Interleukin-12 （IL-12） is produced by antigen presenting cells, for instance, macrophage cells. IL-12 is a cytokine that exerts immunoregulatory effects on T cells and NK cells, playing a unique role in promoting type 1 T helper cell responses and, thereby, cell-mediated immunity. IL-12 has been shown to exert striking therapeutic effects in mouse tumor models and in mouse models of a variety of infectious diseases. Many different treatment means and combinations of IL-12 with certain other cytokines or with radiotherapy or chemotherapy have been attempted. Now, we give a review of biological function and pharmacologic effects of IL-12.

关 键 词：白细胞介素-12 药效学 药代动力学 免疫学 

分 类 号：R96[医药卫生—药理学]