实验性糖尿病小鼠视网膜电图振荡电位的变化  

Changes of ERG oscillation potential on experimental diabetic mice

作　　者：郑奇[1] 袁志兰[1] 戈应滨[2] 

机构地区：[1]南京医科大学第一附属医院眼科,中国江苏省南京市210029 [2]南京医科大学生理学教研室,中国江苏省南京市210029

出　　处：《国际眼科杂志》2008年第6期1162-1164,共3页International Eye Science

摘　　要：目的:探讨高血糖对糖尿病小鼠视网膜电图振荡电位(OP)的影响。方法:C57BL/6雄性小鼠80只分为正常组10只和糖尿病组70只。糖尿病组用STZ造模,4wk后将符合条件的小鼠纳入观察组。检测4,8,12,16,20wk时小鼠OP的表现。结果:在STZ诱导造模后,糖尿病组小鼠与对照组相比体质量增长明显降低,差异有明显统计学意义(P<0.05);建模后糖尿病组血糖明显高于对照组,差异有统计学意义(P<0.01);建模后4wk起,糖尿病小鼠视网膜电图OP1,OP2,OPs振幅有下降趋势,峰潜时延长,与对照组小鼠相比差有统计学意义(P<0.01);20wk时糖尿病小鼠OP1,OP2,OPs振幅降低,峰潜时延迟,与4wk时比较差异有统计学意义(P<0.01)。结论:高血糖可使糖尿病小鼠OP振幅下降,峰潜时延长;且随病程的延长其影响逐渐增强。AIM： To investigate the effects of hyperglycemia on oscillation potential （OP） in the diabetic mice. METHODS： Eighty C57BL / 6 male mice were divided into control group （10 mice） and diabetes group （70 mice）. Mice in diabetes group were made by STZ injection and those accorded with requires were included in observation group after 4 weeks. All of them underwent OP test at the 4, 8, 12, 16, 20 weeks after injection.. RESULTS： The body masses of mice were decreased in STZ-induced diabetes group compared with control group, there are obviously significant differences（P〈 0.01 ）. Blood glucose of modeling was significantly higher than that of control group, the difference was significant （ P〈 0.01 ）. After 4 weeks from modeling,the amplitude of OP1, OP2 and OPs in diabetes group were significantly lower than those in control group , the latencines were delayed in diabetic group （ P 〈 0.01 ）. The results also showed the differences in the amplitude and latencines of the diabetic mice between the 20th and 4th weeks（ P〈 0.01 ）. CONCLUSION. Hyperglycemia affects the amplitude and latencines of OP and its impact has been gradually strengthened with time.

关 键 词：高血糖 糖尿病 视网膜病变 视网膜电图 视网膜振荡电位 小鼠 

分 类 号：R587.1[医药卫生—内分泌] R774.12[医药卫生—内科学]