IL-10基因多态性与肺部感染性疾病关系的研究进展  

An Investigation of the Relationship Between Interleukin-10 Gene Polymorphism and Pulmonary Infectious Diseases

作　　者：杜晓华[1] 李为民[1] 

机构地区：[1]四川大学华西医学院,四川成都610041

出　　处：《昆明医学院学报》2008年第B06期157-160,共4页Journal of Kunming Medical College

摘　　要：白介素-10(IL-10)是一个有力的抗炎和免疫调节因子,它通过抑制炎症因子和趋化因子的合成、抑制细胞介导的免疫反应,从而起到抗炎和免疫调节作用.本文就IL-10的分子生物学特点、细胞分布、IL-10的启动子区域的几个基因的多态性与肺部感染性疾病的关系作一综述.Interleukin-10 （IL-10） is a potent regulatory cytokine that reduces inflammation and regulates immune reaction .The anti-inflammation and immunoregulation of interleukin-10 are performed through having effect on release of inflammation mediators and chemotatic factor and inhibiting cell-mediated immune reaction. In this perspective we are going to review several aspects of IL-10 including molecular biology, cell distribution of IL-10 and the relationship between interleukin-10 promoter gene polymorphism and pulmonary infectious diseases.

关 键 词：白介素-10 基因多态性 感染性疾病 

分 类 号：R56[医药卫生—呼吸系统]