IgG抗体及其亚类在超敏反应中的作用  

Roles of IgG antibody and its subunits in hypersensitivity

作　　者：杨静[1] 乔海灵[1] 

机构地区：[1]郑州大学临床药理学研究所,河南郑州450052

出　　处：《中国药理学与毒理学杂志》2008年第3期233-236,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：河南省杰出青年基金资助项目(0312002100);河南省自然科学基金资助项目(0211040100);河南省医学创新人才工程项目(2002114)~~

摘　　要：IgE抗体与超敏反应尤其是速发型超敏反应的关系已得到公认,IgG抗体在超敏反应中的作用至今尚未阐明。IgG抗体分为IgG1,IgG2,IgG3和IgG44个亚类。针对不同的过敏原、过敏阶段及患者过敏体质IgG抗体亚类对超敏反应的发生可发挥介导或抑制作用。随着人们对IgG抗体及其亚类认识的逐步深入,IgG抗体及其亚类在超敏反应中的作用、在诊断和治疗中的应用将逐步得到阐明。It is generally believed that the immediate hypersensitivity is mediated by specific IgE antibody. But the roles of IgG antibody and its subunits in hypersensitivity have not been sufficiently clarified. Four subunits of IgG （IgG1, IgG2, IgG3 and IgG4） have been identified. The IgG subunits have different roles, for example, induction or inhibition of hypersensitivity, according to the different antigens, hypersensitive phases and atopic patients. With the more knowledge of IgG subunits, the roles of IgG subunits in hypersensitivity occurrence, diagnosis and therapy will be understood.

关 键 词：抗体 超敏反应 免疫球蛋白G 免疫球蛋白亚类 

分 类 号：R392.8[医药卫生—免疫学] R967[医药卫生—基础医学]