国人阴茎血管神经的解剖及临床意义  

Study on the reversing effects of modulators on adriamycin-resistant human bladder cancer cell line BIU-87'ADM

作　　者：朱保平[1] 胡礼泉[1] 郑新民[1] 李世文[1] 王行环[2] 

机构地区：[1]湖北医科大学附属第二医院泌尿外科,武汉430071 [2]广东省人民医院

出　　处：《中华实验外科杂志》1997年第5期308-309,共2页Chinese Journal of Experimental Surgery

摘　　要：目的:了解国人阴茎血管神经的分布,为临床诊治阳萎提供理论依据.方法:对9具成年男性尸体阴茎血管神经进行解剖.结果:背浅静脉主要回流到左侧大隐静脉,背深静脉和海绵体静脉都回流到髂内静脉,三者之间有许多交通支.海绵体静脉和脚静脉位置较深,周围有动脉和神经伴行.海绵体神经肉眼可见,沿前列腺后外侧和直肠壁之间上行入盆腔.The purpose of this in vitro study was to establish effective treatment regimens for overcoming multidrug resistance. BIU-87/ADM is a cell subline with multidrug resistance established in our laboratory by long-term induction with adriamycin. BIU-87 parent cells and multidrug resistant BIU-87/ADM cells were treated with daunorubicin (DNR) or etoposide (EPEG) combined with cyclosporine A (CsA), quinine (Quin), persantine (PST) or amphototicini B (Amp B). The cytotoxicity was measured by MTT assay. The results showed that four regimens significantly enhanced the cytotoxic effects of DNR or EPEG on BIU-87/ADM, with 1. 5 to 15 fold increase in cytotoxic activity and with 18. 2% to 89. 5 % in reversing factor, but had minimal effects on BIU-87 sensitive cell line. These results indicated that inhibited P-glycoprotein (P-gp) through binding to anticancer drugs played an important role in overcoming multidrug resistance, and CsA, Quin, PST and AmpB were effective P-gp modulators and might be used in clinical trail to reverse multidrug resistance.

关 键 词：中国人 阴茎 血管神经 解剖 阳萎 

分 类 号：R698.1[医药卫生—泌尿科学] R329.464[医药卫生—外科学]