缩窄门静脉主干1/2加丝线慢性栓塞术制备犬门静脉高压症模型  

Preparation or canine portal hypertension model by half constriction and silk embolism of portal vein

作　　者：李宗芳[1] 刘效恭[1] 王英[1] 高寰[1] 刘振堂[2] 韩庆[1] 吴涛[1] 蔡根喜[3] 

机构地区：[1]西安医科大学第二临床医学院普外科,710004 [2]西安医科大学第二临床医学院放射科,710004 [3]西安医科大学第二临床医学院外科动物实验室,710004

出　　处：《中华实验外科杂志》1997年第5期314-315,共2页Chinese Journal of Experimental Surgery

基　　金：陕西省重点科技项目资金资助

摘　　要：目的:探索操作简便且效果满意的门静脉高压症动物模型制备方法.方法:缩窄门静脉主干1/2加丝线慢性栓塞术,通过22条犬进行实验.结果:除1条死亡外.其余21条术后3～4周时门静脉压力升高至2.83±0.66kPa(术前1.33±0.28kPa,P<0.001):胃镜、门静脉造影及病理学检查证实,17条犬有食管胃底曲张静脉形成,形成率80.95%(其中方法完善后制备的14条、形成率100%),12条发生门脉高压性胃病,发生率57.14%.1条观察至术后4月.门静脉高压症表现仍然存在.结论:该法简便易行、建立模型周期短、成功率高且质量可靠并较持久.In order to establish a simply operated and satisfactory animal model of portal hypetension, half constriction and silk embolism of portal vein were performed in 22 dogs. Among these dogs, one died and the others were alive during the whole process. The living aminals portal pressure went up to (2.83±0.66)kPa 3-4 weeks after operation. The other examinations showed that 17 dogs (80. 97%) had esopha-gogastric varices. Among the 17 dogs. 14 dogs were perfect in formation of portal hypertension and portal hypertentive gastropathy was developed in 12 dogs (57.14%). The method had characteristics of quick formation and long-term maintaining.

关 键 词：动物模型 门脉高血压 栓塞术 丝线 

分 类 号：R657.34[医药卫生—外科学]