小儿免疫抑制酸性蛋白测定50例分析  

Serum immunosuppressive acidic protein in children:An analysis in 50 cases

作　　者：沈朝斌 王华[1] 季玮[1] 孙金平[1] 姚乐[1] 沈月兰 

机构地区：[1]上海市中西医结合医院

出　　处：《蚌埠医学院学报》1997年第5期313-314,共2页Journal of Bengbu Medical College

摘　　要：目的：试图通过对非肿瘤患者的免疫抑制酸性蛋白（ＩＡＰ）检测来了解在炎症过程中的异常检出率及对免疫细胞抑制方面的影响。方法：用单向琼脂免疫扩散法测定５０例住院小儿肺炎患者的血清ＩＡＰ值，和用流式细胞术方法检测部分患儿外周血细胞表面标记。以ＩＡＰ５００μｇ／ｍｌ为限，分增高组和非增高组，两组免疫细胞等方面的数据采用ｔ检验处理。结果：肺炎患儿中４４％（２２／５０）ＩＡＰ值升高，ＩＡＰ升高组和ＩＡＰ正常组免疫细胞增殖分化等差异均无显著性（Ｐ＞０．０５）。结论：ＩＡＰ增高并非肿瘤所特有，ＩＡＰ的生理功能有待探讨。Objective:Immunosuppressive acidic protein(IAP),a serum immunosuppressive substance,has been identified as a marker for cancers detection in some solid tumors and hematologic diseases.The purpose of this study is to explore the abnormal rate of IAP and its suppressive effects on immunocytes in infectious diseases,and to show that IAP is not only a tumor relative marker but also a nonspecific inflammatory associated factor.Methods:50 children with pneumonia in the pediatrics ward were examined for serum IAP levels with single radial immunodiffusion assay and immunocytes surface markers with flow cytometry.Results:According to the data,the patients were divided into two groups:elevated group(>500 μg/ml) and normal group.The two groups were compared by means of Student t test.The results showed that 44%(22/50) of the serum IAP levels were elevated.But,the difference in proliferation and differrentiation of the immunocytes between the two groups was not significant( P >0.05).Conclusions:Elevation of IAP level is not specific for cancer.the physiological function of IAP is to be discussed.

关 键 词：肺炎 儿童 IAP 血清 

分 类 号：R725.631[医药卫生—儿科] R446.112[医药卫生—临床医学]