联合应用PS及机械通气治疗新生儿呼吸窘迫综合征  

A Clinical Trial of Neonatal Respiratory Distress Syndrome Treated With Pulmonary And Mechanical Ventilation

作　　者：李志奇[1] 都鹏飞[1] 茅双根[2] 薛良荣[2] 

机构地区：[1]安徽医科大学第一附属医院儿科,安徽合肥230001 [2]皖南医学院附属弋矶山医院儿科

出　　处：《解剖与临床》2008年第3期193-195,共3页Anatomy and Clinics

摘　　要：目的:探讨肺表面活性物质联合机械通气治疗新生儿呼吸窘迫综合征的疗效。方法:联合应用肺表面活性物质和机械通气治疗25例新生儿呼吸窘迫综合征患儿,对治疗前后临床表现、动脉血气、呼吸机参数、胸部X线变化等进行观察。结果:用药后患儿临床症状明显好转,胸部X线透亮度明显改善、颗粒网状阴影消失,血气分析及机械通气参数如FiO2、PIP、PEEP值明显降低(P<0.01)。结论:肺表面活性物质联合机械通气能迅速有效地治疗新生儿呼吸窘迫综合征。Objective： To expore effects of pulmonary surfactant （PS） combined with mechanical ventilation on neonatal respiratory distress syndrome （NRDS）. Methods： Twenty-five newborns with NRDS were treated with PS and mechanical ventilation, their clinical symptoms, blood-gas analysis, X-ray chest films, the parameters related to mechanical ventilation were observed and analyzed before and after treatment. Results： After treatment with PS and mechanical ventilation, these newborns got obviously improvement in clinical symptoms and X-ray chest films in which the lucency was increased and grains-ramified shades disappeared. The values of blood-gas analysis and the parameters related to mechanical ventilation such as fraction of inspired oxygen （ FiO2 ） , peak inspiratory pressure （PIP） , and positive end expiratory pressure （PEEP） were decreased. Conclusion： PS combined with mechanical ventilation is an effective and rapid way to treat NRDS.

关 键 词：新生儿呼吸窘迫综合征 肺表面活性物质 机械通气 

分 类 号：R722.1[医药卫生—儿科]