线性模型在研究认知任务行为学效应与脑功能磁共振信号关系中的应用  

Application of Linear Models in Exploring the Relations between Behavior Data and Functional Magnetic Resonance Signals of Brain during Cognitive Task

作　　者：刘加成[1,2,3] 白净[1] 郭启勇[4] 张德玄[5] 

机构地区：[1]清华大学生物医学工程系,北京100084 [2]东南大学附属中大医院放射科,江苏南京210009 [3]美国康奈尔大学医学院附属Methodist医院放射科,美国休斯顿77030 [4]中国医科大学附属盛京医院放射科,辽宁沈阳110004 [5]北京大学心理学系,北京100871

出　　处：《航天医学与医学工程》2008年第4期348-351,共4页Space Medicine & Medical Engineering

基　　金：国家自然科学基金(30670577,60571013,60331010);973(2006CB705700);国家863计划(2006AA020803)

摘　　要：目的建立联系认知任务行为学效应与功能磁共振信号的线性模型,并验证模型合理性。方法通过线性模型建模认知任务行为学效应与功能性磁共振成像(fMRI)信号,通过相关参数的假设检验来确定功能区,并利用Stroop范式的实验数据,对本模型与SPM的分析结果进行比较。结果该模型应用于真实数据,检出的功能区主要有背外侧前额叶(Brodmann9/46),额上内侧回(Brodmann8/9)与SPM结果吻合,与文献报道一致。结论该模型可以定量分析行为学数据与功能信号的关系,为认知功能影像的分析提供了一个思路。Objective To build the linear models for exploring relations between behavior data and functional magnetic resonance image （fMRI） signals of brain during cognitive task and to validate whether it is reasonable. Methods The linear models of behavior data and fMRI signals were built, and the functional regions of brain were detected by tests of corresponding parameters. Experimental data of Stroop tasks were used to study the effects of the models by comparing with the results of SPM. Results The results of Stroop data showed that dorsal lateral prefrontal cortex （ Brodmann 9/46） ,and superior frontal median cortex （Brodmann 8/9） were associated with response time of Stroop tasks, and accorded with SPM results and other reports. Conclusion The models can quantitatively analyze the relations of response time and fMRI signals, providing a new way to explore functional images of cognition.

关 键 词：STROOP效应 线性模型 功能磁共振成像 认知任务 

分 类 号：R857.1[医药卫生—航空、航天与航海医学]