家兔失血性休克及高渗氯化钠治疗后血浆EDLIS变化  

AN EXPERIMENTAL STUDY OF PLASMA EDLIS CHANGES DURING HAEMORRHAGIC SHOCK AND AFTER TREATMENT WITH HYPERTONIC NaCl SOLUTION

作　　者：戴泽平 蒋昭祥 

机构地区：[1]附属弋矶山医院麻醉科

出　　处：《皖南医学院学报》1997年第3期228-230,共3页Journal of Wannan Medical College

摘　　要：20只雄性家兔随机分成A、B两组，实验组A治疗采用静脉滴注7．5％氯化钠6ml／kg，对照组B静脉滴注平衡盐液6ml／kg。用放射兔疫方法测定失血性休克期间及两组治疗后血浆EDLIS变化。结果显示：失血性休克期间血浆EDLIS较休克前明显降低（P＜0．01）。治疗后A组升高（P＜0．05），B组变化不明显，两级相比有显著差异（P＜0．05）。血浆EDLIS水平与同时相的动脉压（r＝0．688）、CVP（r＝0．575）和血Na+浓度（r＝0．382）呈显著正相关（P均＜0．01）。作者认为：①失血性休期间血浆EDLIS降低可能会加速Na+－K+泵机能衰竭；②EDLIS可能至少部分介导高渗氯化钠的抗休克作用。Male rabbits(20) were randomly divided into 2 groups and the moddl of haemorrhagicshock was established with wigger's method modified. The animals in group A were treated with7. 5 % NaCl solution and group B with balanced electrolyte solution (6ml/kg iv. gtt., respectively).Endogenous digoxin-like immunoreactive substance (EDLIS) was measured with radioimmunoassay.The results showed a definite decrease of plasma EDLIS in both groups during haemorrhagic shock (P＜0. 01 ) and a significant increase (P＜0. 05) in group A after treatment. The EDLIS levels were ofsignificantly positive correlation (P＜0. 01, respetively ) with Direct Arterial Pressure (DAP, r=0.688, CVP,r=0. 575 ) and plasma Na+ concentrations (r=0. 382 ). It was deduced that the changeof EDLIS during haemorrhagic shock might be harmful to Na+-K+-ATPase, and that the therapeuticeffect of 7.5% NaCl solution might at least be partially mediated by EDLIS.

关 键 词：地戈辛 失血性休克 高渗盐液 休克 EDLIS 

分 类 号：R605.971[医药卫生—急诊医学]