健力舒纯粉对佐剂性关节炎模型大鼠肿瘤坏死因子-α释放的影响研究  

Effect of Dexarmthasome of Jianlishu Powder on the Release of Tumor Necrosis Factor-α in Rats of Adjuvant-induced Arthritis Model

作　　者：李杰 肖柳英[2] 潘竞锵[2] 罗仲堃[2] 

机构地区：[1]广州市药材公司,广州市510140 [2]广州市中医院中医中药研究所,广州市510130

出　　处：《中国药房》2008年第18期1373-1374,共2页China Pharmacy

摘　　要：目的:研究健力舒纯粉对佐剂性关节炎大鼠肿瘤坏死因子-α(TNF-α)释放的影响。方法:采用大鼠足跖注射Freundi's完全佐剂形成佐剂性关节炎(AIA),观察健力舒纯粉对模型大鼠超敏反应、炎症左右足跖厚度差异及血清TNF-α、白细胞介素-2(IL-2)和循环免疫复合物(CIC)的含量变化。结果:模型大鼠右后跖从第2天开始肿胀持续15d(原发性损害),健力舒纯粉可依赖性抑制模型大鼠足肿胀的程度,抑制TNF-α、IL-2的释放和降低CIC含量而发挥抗炎作用。结论:健力舒纯粉具有抗AIA、降低致炎因子及相关炎症介质的作用。OBJECTIVE： To study of effects of dexarmethasome of Jianlishu Powder on the release of tumor necrosis factor - α in rats of adjuvant arthritis model. METHODS： Adjuvant - induced arthritis （AIA） was induced by injection of frenndi＇ s complete adjuvant in rats＇ plantar to observe the effects of Jianlishu Powder on rice＇ hypersensitivity reaction, thickness of inflamed plantar of both feet, and levels of tumor necrosis factor-α（TNF-α）, Interleukin- 2 （IL-2） and circulating immune complex （CIC） in AIA rats. RESULTS： rats＇ right posterior metatarsus which was injected with adjuvant was swollen from the second day for 15 days （primary lesion）. Jianlishu Powder significantly inhibited feet swelling induced by collagen dose - dependently and down - regulate the contents of TNF - α, IL - 2 and CIC thus resulting in an anti - inflammatory action in AIA rats（P〈0.01） .CONCLUSION： J ianlishu Powder possesses the ability against AIA, meanwhile, it can down- regulate proinflammatory agents and related inflammatory mediators.

关 键 词：健力舒纯粉 佐剂性关节炎 肿瘤坏死因子-α 白细胞介素-2 循环免疫复合物 大鼠 

分 类 号：R285[医药卫生—中药学] R944[医药卫生—中医学]