神昌注射液中β-细辛醚、冰片的氧化及异构体转换分析  

Oxidation and isomerous conversion of β-asarone and borneol in Shenchang Injection

作　　者：魏刚[1] 何建雄[1] 

机构地区：[1]广州中医药大学第一附属医院实验中心,广东广州510405

出　　处：《中草药》2008年第6期841-843,共3页Chinese Traditional and Herbal Drugs

基　　金：广东省科技厅资助项目(2003C34403);广东省科技厅产业技术研究与开发资金计划资助项目(2007B060401011)

摘　　要：目的 探讨神昌注射液氧化变色后有何产物生成和β-细辛醚、冰片在其中的氧化机制及异构体的转换情况。方法 采用GC-MS对神昌注射液氧化变色前后的样品进行分析，及对β-细辛醚、冰片灭菌前后的成分进行比较。结果 3批次神昌注射液氧化变色后，其中β-细辛醚部分氧化生成了0．88％～2．82％的细辛醛、0．24％～0．46％的细辛酮，冰片中的龙脑与异龙脑部分氧化生成了樟脑；经100℃灭菌30min后，β-细辛醚（顺式）异构体转换生成约1％～2％的a-细辛醚（反式），冰片中（7．85±7．27）％的异龙脑（顺式）异构化为龙脑（反式）。结论 神昌注射液中的β-细辛醚、冰片均参与了氧化反应，高温灭菌后也发生了异构体的转换。Objective To analyze what will create after oxidation in Shenchang Injection, the oxidated mechanism, and isomerous conversion of β-asarone and borneol in it. Methods To analyze the sample of Shenchang Iniection before and after oxidation by GC-MS and to compare the composition of β-asarone and borneol before and after sterilization. Results Some of β-asarone was oxidized and changed to asary-laldehyde （about 0. 88%--2.82% of total composition ） and saishinone （about 0. 24%--0. 46% of total composition）, some of the borneol and isoborneol was oxidized and changed to camphor when three sampies of Shenchang Injection are oxidized; some of β-asarone （cis-） change to a-asarone （trans-, about 1%-2%）, （7. 85±7.27）% of the isoborneol （cis-） changed to borneol （trans-） when sterilized at 100 ℃ for 30 rain. Conclusion β-Asarone and borneol in Shenchang Injection are involved in the oxidated reaction and have isomerous conversion after high pressure sterilization.

关 键 词：神昌注射液 Β-细辛醚 冰片 异构体转换 GC-MS 

分 类 号：R286.1[医药卫生—中药学]