东莨菪碱对大鼠下丘脑室旁核精氨酸升压素的影响  

INFLUENCE OF SCOPOLAMINE ON THE CONCENTRATION OF ARGININE-VASOPRESSIN IN RAT PARAVENTRICULAR NUCLEUS

作　　者：李太志 顾雪英[1,2] 杨俊[1,2] 

机构地区：[1]上海教育学院生理学教研室 [2]上海第二军医大学神经生物学教研室

出　　处：《徐州医学院学报》1997年第4期366-368,共3页Acta Academiae Medicinae Xuzhou

摘　　要：观察东莨菪碱（ｓｃｏｐｏｌａｍｉｅ，Ｓｃｏｐ）对大鼠下丘脑旁室核精氨酸升压素的影响。方法以不同浓度Ｓｃｏｐ推挽灌流大鼠下丘脑室旁核（ｐａｒａｖｅｎｔｒｉｃｕｌａｒｎｕｃｌｅｕｓ，ＰＶＮ）。结果挽出液中精氨酸升压素（ａｒｇｉｎｉｎｅ－ｖａｓｏｐｒｅｓｓｉｎ，ＡＶＰ）含量随推挽时间延长而增多。结论Ｓｃｏｐ可促进ＰＶＮ释放内源性ＡＶＰ，这对了解Ｓｃｏｐ抗休克的机理有重大的意义。Objective To observe the influence of scopolamine (Scop) on the concentration of arginine-vasopressin (AVP) in the paraventricular nucleus (PVN) in rats.Method Push-pull technique was used to perfuse the PVN with Scop of varied concentrations.ResultThe concentration of AVP in pulled-out fluid increased with the concentration of Scop and the length of perfusion time.Conclusion Scop stimulates the release of intrinsic AVP. Theresults would helpinunderstanding the mechanism of Scop′s antishock effect.

关 键 词：室旁核 东莨菪碱 精氨酸升压素 休克 治疗 

分 类 号：R441.9[医药卫生—诊断学]