乙醇-水混合溶剂中5′-尿苷酸二钠的结晶介稳区  

Metastable zone of 5′-UMPNa_2 in ethanol-aqueous mixture

作　　者：张磊[1] 应汉杰[1] 吕浩[1] 马骏[1] 

机构地区：[1]南京工业大学制药与生命科学学院,江苏南京210009

出　　处：《化工学报》2008年第6期1348-1353,共6页CIESC Journal

基　　金：国家重点基础研究发展计划项目(2007CB714305)~~

摘　　要：采用双光路激光法,在293.2-318.2K温度范围内,研究了5＇-尿苷酸二钠在不同比例乙醇-水混合溶剂中的溶解与超溶解特性,得到了5＇-尿苷酸二钠的结晶介稳区。采用λh方程关联了4个体系的溶解度数据,进而分别求得各体系下的混合焓和结晶焓。同时,探讨了搅拌转速、pH值和钠离子浓度对结晶介稳区的影响。实验结果表明,与温度相比较,乙醇质量分数是影响溶解度和超溶解度的主要因素;随乙醇质量分数的增大,5＇-尿苷酸二钠的溶解度和超溶解度显著减小;在相同条件下,溶液pH值和钠离子浓度的升高,以及搅拌转速的降低均会增大5＇-尿苷酸二钠结晶介稳区的宽度。The dual circuits laser detector was used to measure the solubility and super-solubility of uridine-5＇-monophosphate disodium salt in the ethanol-aqueous mixture of different ethanol mass fractions at 293.2—318.2 K.In addition, the effects of agitation rate, pH value and Na＋ concentration on the width of metastable zone were explored respectively.It was found that the solubility data might be described well by the model of λh equation; furthermore the mixing enthalpy and the crystallization enthalpy of uridine-5＇-monophosphate disodium salt in mixture were determined.Similar to the solubility, the super-solubility increased with the increase of temperature and decreased with the increase of ethanol mass fraction.Under the same experimental conditions, increase of pH value, Na^＋ concentration or decrease of agitation rate might broaden the width of metastable zone.

关 键 词：5'-尿苷酸二钠 溶解度 介稳区 λh方程 

分 类 号：TQ465.1[化学工程—制药化工] TQ026.5