多壁碳纳米管修饰电极上阿替洛尔电化学行为的研究及其测定  

Electrochemical behavior of atenolol at multi-wall carbon nanotubes modified glassy carbon electrodes and its analytical application

作　　者：李晓霞[1,2] 申丽华[1] 王姝[1] 漆红兰[1] 

机构地区：[1]陕西省生命分析化学重点实验室,陕西师范大学化学与材料科学学院,西安710062 [2]延安大学化学与化工学院,延安716000

出　　处：《分析试验室》2008年第6期1-4,共4页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金(90607016)项目资助

摘　　要：基于多壁碳纳米管修饰玻碳电极对阿替洛尔的催化作用，建立了测定阿替洛尔的电化学分析方法。多壁碳纳米管修饰玻碳电极与裸玻碳电极相比，显著提高了阿替洛尔的氧化峰电流，降低了氧化峰电位，提高了测定的灵敏度。该电极测定阿替洛尔的线性范围为4．9×10^-6．3×10^-4mol／L，检出限为2×10^-6mol／L。对1．3×10^-4mol／L阿替洛尔进行11次平行测定，相对标准偏差为4．4％。此法可用于阿替洛尔片剂中阿替洛尔的测定。Electrochemical behavior of atenolol and its analytical application were investigated at muhi-wall carbon nanotubes （MWNT） modified glassy carbon electrodes （GCE）. An irresivible oxidation peak was observed at 773 mV at a the MWNT/GCE while an irresivible oxidation peak appeared at 1129 mV at bare GCE. The electrochemical response of atenolol was greatly improved at MWNT/GCE, compared with that at the bare GCE. Under optimal conditions, there was a good linear relationship between anodic peak current and atenolol concentration in the range from 4.9 ×10^-6 to 6.3 ×10^-4 mol/L with a detection limit of 2 ×10^-6 mol/L （S/N = 3）. The MWNT/GCE has been applied to the determination of atenolol in drug with good results.

关 键 词：多壁碳纳米管 阿替洛尔 化学修饰电极 电化学 

分 类 号：O657.1[理学—分析化学]