氧化镁膜AZ31B镁合金材料的细胞毒性研究  

Cytotoxicity of AZ31B Magnesium Alloy Covering with Magnesium Oxide

作　　者：郭磊[1] 刘魁[1] 张世亮[1] 黄晶晶[2] 谭丽丽[2] 杨柯[2] 

机构地区：[1]中国医科大学,辽宁沈阳110001 [2]中国科学院金属研究所,辽宁沈阳110016

出　　处：《稀有金属材料与工程》2008年第6期1027-1031,共5页Rare Metal Materials and Engineering

基　　金：国家自然科学基金项目(30500414);辽宁省教育厅高等学校科学研究项目(05L508)资助

摘　　要：利用恒电流阳极氧化技术制备氧化镁(MgO)表面膜的AZ31B镁合金材料(MgO/AZ31B),观测材料在体外生理环境中的微观形貌,评价材料的细胞毒性作用以及对体外培养的成骨细胞功能的影响。结果表明,MgO膜可有效地延缓AZ31B镁合金降解产物的释放速度,显著降低合金的致突变反应和溶血反应,对成骨细胞的增殖和成骨活性无毒性作用。在骨组织工程领域内MgO/AZ31B材料可望成为新型可降解生物医学材料。The magnesium alloy AZ31B with magnesium oxide （MgO/AZ31B） film has been electrosynthesized by anodic oxidation technique at a constant current. The microstructure and cytotoxic effect of the magnesium alloy were detected. The effects of MgO/AZ31B magnesium alloy on the function of osteoblast were evaluated in vitro. The results show that the release and degradation processes of AZ31B magnesium alloy are efficiently delayed by coating with MgO, whereas the mutagenesis and hemolytic reactions of AZ31B magnesium alloy are degraded. It is shown that he MgO/AZ31B magnesium alloy does not affect the proliferation and the bone formation of osteoblast by the direct contact test in vitro. Therefore, the MgO/AZ31B magnesium alloy would be a new degradable and biomedical material.

关 键 词：镁合金 氧化镁 成骨细胞 细胞毒性 

分 类 号：R318.08[医药卫生—生物医学工程]