艾灵颗粒对HIV感染者外周血树突状细胞亚群的影响  

Effect of Ailing granule on peripheral dendritic cell subsets in individuals infected with HIV

作　　者：危剑安[1] 刘婧[1] 王福生[2] 宋春鑫[1] 张政[2] 金燕[1] 薛柳华[1] 周伟[1] 徐暄[1] 黄霞珍[1] 

机构地区：[1]中国中医科学院广安门医院艾滋病研究室,北京100053 [2]中国人民解放军302医院生物治疗研究中心,北京100039

出　　处：《中国艾滋病性病》2008年第3期235-237,共3页Chinese Journal of Aids & STD

基　　金：北京市科技计划“艾滋病防治策略及综合防治研究”(D0906003040791)

摘　　要：目的观察中药艾灵颗粒治疗艾滋病病毒(HIV)感染者外周血树突状细胞(Dendritic cell,DC)亚群变化特点。方法收集未接受高效抗逆转录病毒治疗(HAART)的17例HIV感染者,采用中药艾灵颗粒治疗9个月,11例健康人作为对照,观察治疗前后症状体征变化。采用流式细胞技术对患者外周血髓样树突状细胞(MDC)及浆细胞样树突状细胞(PDC)频率进行检测,并对PDC产生α-干扰素(IFN-α)能力进行检测。结果疗后3个月、9个月,MDC频率与疗前的差异有统计学意义(P<0.05),疗后9个月,PDC频率与疗前的差异有统计学意义(P<0.05),均从疗前低于健康对照水平恢复到疗后健康对照水平。疗后9个月IFN-α均值升高,与疗前的差异有统计学意义(P<0.01)。结论艾灵颗粒可能在一定程度恢复MDC和PDC频率,升高PDC分泌IFN-α的作用,提高感染者免疫功能。Objective To investigate the change of peripheral dendritic cell（PDC）subsets in individuals infected with HIV who were treated with Ailing granule, a traditional Chinese drug. Method Seventeen cases who had not taken antiviral medicines were treated with AiLing granule for 9 months. Eleven cases were set as normal control. The percentages of PDC and MDC were determined by flow cytometry. At the same time, the ability of PDC to produce IFN-α was also detected. Results The percentage of MDC in individuals treated with Ailing granule for 3 or 9 months was significantly higher than that before the treatment, and returned to a normal level. The percentage of PDC in individuals treated for 9 months was significantly higher than that before-treatment and also returned to a normal level. The value of IFN-α in individuals treated for 9 months was elevated and had statistically significant difference as compared with that before treatment. Conclusion Ailing granule could increase to a certain extent the percentages of MDC and PDC and elevate the ability of PDC to produce IFN-α, thus raising immunity of the infected individuals.

关 键 词：艾灵颗粒 艾滋病病毒感染者 树突状细胞亚群 

分 类 号：R373.9[医药卫生—病原生物学] R289[医药卫生—基础医学]