从高原急进特高海拔地区人体血浆内皮素-1水平的变化及其意义  

PLASMA LEVELS OF ET-1 IN SUBJECTS ACUTE EXPOSED TO EXTREME ALTITUDE FROM 3 658m ALTITUDE

作　　者：薛增军[1] 李英悦[1] 宋强华[1,1] 

机构地区：[1]西藏军区总医院全军高山病防治中心

出　　处：《高原医学杂志》1997年第4期23-24,共2页Journal of High Altitude Medicine

摘　　要：目的：为探讨ET—1在高原地区及急进特高海拔地区的变化及其对急慢性高原病的意义；方法：对20名健康战士在高原（3658m）和急进特高海拔（4700m）后的血浆ET—1水平进行检测，同时检测了两地的血氧饱和度（SaO2）；结果而原地区的ET—1水平明显高于平原参考值（P＜0．05），急进海拔4700m后EF－1水平更显著的增高（P＜0．01），且与SaO2呈明显负相关（P＜0．01，r＝0．628）。结论：在高原地区及急进特高海拔后ET—1水平皆增高，FT—1水平的增高是急慢性高原病发病的重要因素。To study ET-1 levels at high altitude of 3 658m and 4 700m. Methods:ET-1 and SaO2 were measured with radioimmunoassary in 20 healthy young objects. Results:ET-1 level at hing altitude of 3 658m was significantly higher than in plain (P<0. 05)and significantly increased in 4 700m(p<0. 01). The SaO2 at 4 700m decreased significantly than that at 3 658m(P< 0. 01 ). Conclusions: There was a negative correlation between SaO2 and ET-1 level (P<0. 01,r=0. 638). The ET-1 could play an important role in formation of AMS and CMS.

关 键 词：高原 急性缺氧 内皮素-1 环境生理 病理 

分 类 号：R339.54[医药卫生—人体生理学] R594.302[医药卫生—基础医学]