嵌段聚合物胶束的胶束化机理与物理稳定性研究  

The mechanism of block copolymer micellization and its physical stability study

作　　者：苗先烽[1] 涂家生[1] 林琳[1] 

机构地区：[1]中国药科大学药剂教研室,南京210009

出　　处：《药学与临床研究》2008年第3期203-207,共5页Pharmaceutical and Clinical Research

摘　　要：嵌段聚合物目前正成功地被应用于水不溶性药物的投送中,并展示出良好的应用前景,但胶束稳定性是这一给药途径的最大难题。本文介绍了聚合物胶束的形成过程及胶束化机理,并从热力学和动力学的角度分别讨论了影响嵌段聚合物胶束物理稳定性的各个因素,同时简述了增强聚合物胶束物理稳定性的方法。Copolymer micelles have been successfully applied in the drug delivery system and have already showed great potential to solubilized hydrophobic drugs and controlled release and so on, But the stability of the micelle has been the greatest obstacle. In this review, we describe the mechanism of the micellization, and discuss different factors that may influence the micelle stability, different ways to enhance the micelle stability have also been reviewed,

关 键 词：嵌段聚合物 动力学 热力学 胶束化 物理稳定性 

分 类 号：R944.75[医药卫生—药剂学]